高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (6): 791.

• 研究论文 • 上一篇    下一篇

[N,N-二-(2-氯乙基)]-O-[O',O'-二烷基膦酰甲基]-N',N'-二烷基磷酰二胺的合成及性质研究

陈茹玉, 张鸣, 毛丽娟   

  1. 南开大学元素有机化学研究所, 天津 300071
  • 收稿日期:1992-09-01 修回日期:1993-02-24 出版日期:1993-06-24 发布日期:1993-06-24
  • 通讯作者: 陈茹玉
  • 基金资助:

    国家博士后科学基金;国家自然科学基金

Studies on the Syntheses and Properties of N',N-(bis-(2-Chloroethyl))-O- (O',O'-dialkyl-phosphorylmethyl)-N', N'-dialkylphosphoryldiamide

CHEN Ru-Yu, ZHANG Ming, MAO Li-Juan   

  1. Institute of Elemnto-Orgatric Chemistry, Nankai University, Tianjin, 300071
  • Received:1992-09-01 Revised:1993-02-24 Online:1993-06-24 Published:1993-06-24

摘要: 合成了6种含有氮芥结构及膦酰甲基取代基的磷酰二胺。其结构经1HNMR、MS和元素分析确定,讨论了它们的性质,并对部分化合物的抗癌活性进行了初步试验。

关键词: 抗癌药物, 磷酰胺, 磷酰二胺

Abstract: Anumber of compounds with the formula (ClCH2CH2)2NP (O) NR21 (OCHRP (O)OR22) have been synthesized.Their 1H NMRspectra and some other properties are discussed.The antitumor properties of these compounds are being tested.It is found that some of them have positive results.

Key words: Antitumor agent, Phosphoramide, Phosphoryl diamide

TrendMD: