高等学校化学学报

高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (6): 787.

• 研究论文 • 上一篇    下一篇

硫代磷(膦)酰基脲类衍生物的合成及其生物活性

杨华铮, 黄战鏖   

  1. 南开大学元素有机化学研究所, 天津 300071
  • 收稿日期:1992-07-29 修回日期:1993-01-18 出版日期:1993-06-24 发布日期:1993-06-24
  • 通讯作者: 杨华铮.
  • 基金资助:

    国家自然科学基金

Syntheses and Biological Activities of Thiophosphoryl (Thiophosphonyl) Urea Derivatives

YANG Hua-Zheng, HUANG Zhan-Ao   

  1. Department of Chemistry, Mm University, Changchun, 130023
  • Received:1992-07-29 Revised:1993-01-18 Online:1993-06-24 Published:1993-06-24

PDF (PC)

被引次数

13

摘要： 通过O,O-二乙基硫代磷酰基异氰酸酯或O-乙基-苯基硫代膦酰基异氰酸酯与不同胺的加成反应,合成了一系列新型硫代磷(膦)酰基脲类化合物,其结构经元素分析、1HNMR及MS确证。初步的生物活性测定表明,这类化合物具有一定的除草、抗肿瘤及抑制几丁质形成活性。

关键词: 取代脲, 硫代磷(膦)酰脲, 生物活性

Abstract: The thiophosphoryl(thiophosphonyl) urea uerivatives, R(EtO)P(S)NHC(O)N (R1)R2, (R=EtO, Ph:R1=alkyl, H; R2=alkyl, aryl and heterocyclic radical) were synthesized by the addition reaction of R(EtO)P(S)NCO (R=EtO, Ph) to various amines respectively and their structures were confirmed by means of elemental analysis, 1H NMRand MS, Hie preliminary biological tests show that these compounds have herbicidal and anti-tumour activities and could inhibit the formation of chitin.

Key words: Substituted ureas, Thiophosphoryi(thiophosphonyi)ureas, Biological activity

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