高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (5): 630.

• 研究论文 • 上一篇    下一篇

冠醚化合物的合成(ⅩⅪ)——开链酰胺型冠醚的合成及其钙离子选择电极的性能

郭斌1, 徐伟1, 刘冬1, 黄载福1, 谌了蓉2, 罗宝生2   

  1. 1. 武汉大学环境科学系, 武汉 430072;
    2. 武汉大学分析测试中心
  • 收稿日期:1991-12-27 修回日期:1993-02-03 出版日期:1993-05-24 发布日期:1993-05-24
  • 通讯作者: 黄载福
  • 基金资助:

    武汉大学分析测试中心开放基金

Syntheses of Crown Ethers (ⅩⅪ)——Syntheses of Polyether of Open Chain Amides and Properties of Its Calcium Ion Selective Electrodes

GUO Bin1, XU Wei1, LIU Dong1, HUANG Zai-Fu1, CHEN Liao-Rong2, LUO Bao-Sheng2   

  1. 1. Dept, of Eevironmental Science, Wuhan Univ., Wuhan, 430072;
    2. Center of Analysis Measurement, Wuhan Univ., Wuhan, 430072
  • Received:1991-12-27 Revised:1993-02-03 Online:1993-05-24 Published:1993-05-24

摘要: 本文以多甘醇为原料,经氧化、取代反应制备了多甘酰氯,再与仲胺反应,合成了7个开链酰胺型冠醚化合物和1个酰胺型大环化合物,除冠醚(Ⅰ)外,其余均未见文献报道。它们的结构经红外、核磁、质谱和元素分析数据确认,并用四圆单晶X射线衍射仪测定了冠醚(Ⅱ)单晶的晶体结构,进一步从理论上说明了它是优良的钙离子选择电极的中性载体。

关键词: 冠醚, 开链酰胺, 中性载体, 钙离子选择电极

Abstract: Eight ligands(Ⅰ -Ⅷ), seven of which were new compounds, were synthesized in this paper.Compounds Ⅰ - Ⅶ are open chain amides and Ⅷ, a macrocyclic lactam.Their structures were determined by IR, 1H NMR, MSand elemental analysis.Calcium ion selective electrodes based on these new neutral carriers were studied, among which a superior carrier was found.Satisfactory results were obtained by using this electrode to determine the calcium ion in human serum.The limit of detection is lower than intracellular free calcium ion activity (1.4×10-7 mol/L) in microelectrode, and were better than electrodes on other crown ethers including ETH1001 and ETH129.

Key words: Crown ether, Open chain amide, Neutral carrier, Calcium ion selective electrode

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