高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (2): 204.

• 论文 • 上一篇    下一篇

双环笼状磷酸酯衍生物的合成(Ⅴ)——1-氧代-1-磷杂-2,6,7-三氧杂双环[2,2,2]-4-取代酰基辛烷的合成

李玉桂, 李建敏, 任海兰, 陈立   

  1. 南开大学元素有机化学研究所, 天津, 300071
  • 收稿日期:1991-03-30 出版日期:1992-02-24 发布日期:1992-02-24
  • 通讯作者: 李玉桂
  • 基金资助:

    国家自然科学基金

Studies of Caged Bicyclic Phosphates(Ⅴ)——Synthesis of 1-Oxo-1-Phospha-2,6,7-Trioxabicyclo[2,2,2]-4-Substituted Carbonyl Octane

LI Yu-gui, LI Jian-min, REN Hai-lan, CHEN Li   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071
  • Received:1991-03-30 Online:1992-02-24 Published:1992-02-24

摘要: 本文利用1-氧代-1-磷杂-2,6,7-二氧杂双环[2,2,2]-4-氯甲酰基辛烷3和硫醇、乙二胺、乙醇胺及一些具有生理活性的杂环化合物反应,合成了13种未见文献报道的化合物4a-n。发现化合物3与8-羟基喹啉作用生成的是水合物。讨论了可能的结构。3与氨作用得到相应的酰胺,合成的化合物均经元素分析、IR和1HNMR证实其结构。本文还研究了部分化合物的MS裂解规律。对部分化合物的生物活性初测表明,化合物4j具有良好的杀菌活性,而无明显的杀虫活性。

关键词: 双环笼状磷酸酯, 杂环化合物, 硫醇, 酰胺

Abstract: Caged bicyclic phosphates would be a new type of pesticides because of their unusual mode of bioaction Also they would be widely used as fire-proofing agents, resin-stabilizers and oil-adductsAs a part of our continuing investigation, other thirteen new derivatives of bicyclic phosphate 4a-n were synthesized by the reaction of 1-oxo-1-phospha-2, 6,7-trioxabicyclo[2,2,2]-4-chlorocarbonyl octane 3 with mercaptans, ethanolamine, ethylene amine, and heterocyclic compoundsAll the compounds were confirmed by elemental analysis, IR and 1H NMR Through studying the spectra of compound 4j, we infered its possible structureThe MSspectra of some compounds were discussedIt is indicated that higher thioesters have the same bi-rear-rangement as usual estersThe preliminary biological tests show that compound 4j has a bactericidal activity.

Key words: Caged bicyclic phosphate, Heterocyrlic compound, Mercaptan, Amide

TrendMD: