高等学校化学学报 ›› 1990, Vol. 11 ›› Issue (5): 540-542.

• 研究简报 • 上一篇    下一篇

醌类化合物与抗坏血酸反应生成醌自由基负离子的ESR研究

张发, 房槐, 陈伟, 刘中立, 刘有成   

  1. 兰州大学应用有机化学国家实验室
  • 收稿日期:1989-01-19 出版日期:1990-05-24 发布日期:1990-05-24
  • 通讯作者: 刘有成
  • 基金资助:

    国家自然科学基金

An ESRtudy on Quinone Radical Anions Formed by the Reaction of Ascorbic Acid with Quinones

Zhang Fa, Fang Huai, Chen Wei, Liu Zhongli, Liu Youcheng   

  1. The National Laboratory OK Applied Organic Chemistry at Lanzhou University, Lanzhou
  • Received:1989-01-19 Online:1990-05-24 Published:1990-05-24

摘要: 醌类化合物广泛存在于动植物体内,许多抗癌药物含有醌核[1]。醌类可经单电子还原生成相应的的醌自由基负离子,后者可转移单电子给分子氧,产生超氧负离子基,并进一步产生对生物细胞有损伤作用的羟基自由基[2,3],这被认为是醌类化合物生物毒性的主要来源之一。

关键词: 醌自由基负离子, 抗坏血酸, 单电子转移

Abstract: Quinone radical anions of p-benzoquinone, 2,5-dimethyl-, 2,6-dimetiiyl-,tert-butyl-, and 2,6-di-tert-butyl-p-benzoquinones, 1,4-naphthaquinone and 2-methylnaphthaquinone were detected by ESR in a water-DMSO mixed solvent with pH = 8. 5 when the corresponding quinones reacted with ascorbic acid. The results were rationalized by the single electron transfer reaction between the quinone and ascorbic acid.

Key words: Quinone radical anion, Ascorbic acid, Single electron transfer