高等学校化学学报

高等学校化学学报 ›› 1990, Vol. 11 ›› Issue (11): 1203.

• 研究论文 • 上一篇    下一篇

具有生物活性的有机硅化合物研究(Ⅺ)——2-(三甲硅基)乙基硫代(N-取代)乙酰胺的研究

谢庆兰, 王明德, 单志兴   

  1. 南开大学元素有机化学研究所, 300071
  • 收稿日期:1989-04-09 出版日期:1990-11-24 发布日期:1990-11-24
  • 通讯作者: 谢庆兰
  • 基金资助:

    中国科学院科学基金

Studies on Organosilicon Compounds with Biological Activity (Ⅺ)——Study of 2-(Trimethylsilyl)Ethylthio(N-Substituted)Acetamide

Xie Qinglan, Wang Mingde, Shan Zhixing   

  1. Institute of Elemeuto-Organic Chemistry, Nonkai University, Tianjin, 300071
  • Received:1989-04-09 Online:1990-11-24 Published:1990-11-24

PDF (PC)

摘要： 研究了2-(三甲硅基)乙基硫代乙酸与(取代)苯胺和脂肪胺直接缩合反应或在五氧化二磷存在下的反应,发现前者收率高于后者。由此合成了17种结构新颖的2-(三甲硅基)乙基硫代(N-取代)乙酰胺类化合物。通过NMR(1H,13C)、IR和MS的研究,确定了这类化合物的结构,并探讨了化合物结构与波谱的关系。经测定,这些化合物的生物活性不甚理想。

关键词: 有机硅化合物, 硫醚, 酰胺, 生物活性

Abstract: Seventeen 2-(trimethylsilyl)ethylthio(N-substituted)acetarnides were synthesized with two different methods. The structures of the products were studied by NMR(1H, 13C), IRand MS. The relationship between spectra and structure of the products was discussed. Results from the preliminary biological tests show that these compounds have weak fungicidal activities.

Key words: Organosilicon Compound, Thioether, Amide, Bioassay

TrendMD: