高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

十二烷基磺酸钠在正丙醇/水混合溶液中囊泡的形成及其性能研究

吴燕茹1，李安明2，高美华2，庄文昌1,2   

  1. 1. 伊犁师范大学 化学化工学院 2. 徐州工程学院 材料与化学工程学院
  • 收稿日期:2025-07-31 修回日期:2025-09-09 出版日期:2025-09-16 发布日期:2025-09-16
  • 通讯作者: 高美华 E-mail:mhgao@xzit.edu.cn
  • 基金资助:
    国家自然科学基金(批准号: 22302165)和江苏省双创博士计划(批准号: JSSCBS20221588)资助

Formation and Properties of Sodium Dodecyl Sulfonate Vesicles in n-Propanol/Water Mixed Solutions

WU Yanru¹, LI Anming², GAO Meihua², ZHUANG Wenchang¹,²   

  1. 1. College of Chemistry and Environmental Science, Yili Normal University 2. School of Materials and Chemical Engineering, Xuzhou University of Technology
  • Received:2025-07-31 Revised:2025-09-09 Online:2025-09-16 Published:2025-09-16
  • Contact: Mei-Hua GAO E-mail:mhgao@xzit.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China(No. 22302165) and the Jiangsu Provincial Double Innovation Doctoral Plan(No. JSSCBS20221588)

PDF (PC)

补充材料

1

摘要： 通过动态光散射（DLS）、透射电子显微镜（TEM）、小角X射线散射（SAXS）及傅里叶变换红外光谱（FT-IR）等技术，系统考察了十二烷基磺酸钠（SDS）在正丙醇（NPP）/水混合溶液中的自组装行为。实验结果表明，NPP的引入显著提升了SDS溶解度，在50 wt% NPP/水混合溶剂中溶解度达286.58 g·L?1，较纯水体系（1.507 g·L?1）提升191倍。研究发现，SDS/NPP/H2O三元体系各向同性相中，除了典型的胶束结构外，还观察到了囊泡聚集体的形成。随着NPP含量的逐步增加，囊泡结构逐渐向胶束转变，当醇含量大于50% NPP时，体系中的聚集体主要以胶束形式存在。通过FT-IR光谱分析证实，SDS与NPP分子间形成的氢键（-S=O···H-O-），同时SDS分子间的“水桥”、“阳离子（Na?）桥”（-SO??···Na?···-SO??）发挥了重要作用，有效抑制了阴离子头基间的静电排斥，这对于SDS/NPP囊泡相的形成起着关键作用。此外，SAXS与原子力显微镜（AFM）证实囊泡双层膜中存在烷基链交叉构型，交叉度为28.57%，这种高度交叉的烷基链结构也是SDS/NPP囊泡形成和稳定的内在原因。SDS/NPP囊泡在长期储存、高温处理以及冻融循环等条件下均表现出良好的稳定性，同时对亲水性染料钙黄绿素具有一定的包覆能力。另外，同时囊泡膜对OH?具有一定的渗透性，其跨膜渗透过程符合一级动力学模型。本研究可加深对单链双亲分子聚集行为的认识，也为单链双亲分子囊泡的实际应用提供有价值的信息。

关键词: 囊泡, 十二烷基磺酸钠, 正丙醇, 自组装

Abstract: The self-assembly behavior of sodium dodecyl sulfonate (SDS) in n-propanol (NPP)/water mixed solutions was studied using methods such as dynamic light scattering (DLS), transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and fourier transform infrared spectroscopy (FT-IR). Experimental results demonstrated that the introduction of NPP significantly enhanced the solubility of SDS. In the 50 wt% NPP/water mixed solvent, the solubility of SDS reached 286.58 g·L?1, representing a 191-fold increase compared to the pure water system (1.507 g·L?1). The study reveals that in the isotropic phase of the SDS/NPP/H?O ternary system, besides the typical micellar structure, vesicle aggregates are also observed. As the NPP content progressively increased, the vesicular structures gradually transformed into micelles. When the alcohol content exceeded 50 wt% NPP, the aggregates within the system primarily existed as micelles. FT-IR spectral analysis confirmed the formation of hydrogen bonds between SDS and NPP molecules (-S=O···H-O-). Concurrently, the “water bridge” and “cation (Na?) bridge”(-SO??···Na?···-SO??) between SDS molecules played crucial roles. These interactions effectively mitigated the electrostatic repulsion between the anionic headgroups, which is pivotal for the formation of the SDS/NPP vesicular phase. Furthermore, SAXS and atomic force microscopy (AFM) confirmed the presence of an interdigitated structure of alkyl chains between two leaflets configuration within the vesicle bilayer membranes, with an interdigitated degree of 28.57%. This highly interdigitated structure of alkyl chains between two leaflets is also an intrinsic factor contributing to the formation and stability of the SDS/NPP vesicles. The SDS/NPP vesicles exhibited excellent stability under various conditions, including long-term storage, high-temperature treatment, and freeze-thaw cycles. Furthermore, they exhibited a notable capacity for encapsulating hydrophilic dyes such as calcein. Additionally, the vesicle membrane demonstrated permeability towards OH? ions, and the transmembrane permeation process conformed to a first-order kinetic model. This study could deepen the understanding of the aggregation behavior of single-chain amphiphiles and provides valuable insights for the practical application of single-chain amphiphilic molecule vesicles.

Key words: Vesicles; Sodium dodecyl sulfonate, Self-assembly, n-Propanol

中图分类号: 

TrendMD: