The Kinetic Studies of Across-Erythrocyte Membrane Transport of Platinium(Ⅱ) Complexes

Abstract

Abstract: In the synthetic plasma, the uptake kinetics of cis-platin and it' s related compounds in human erythrocytes was studied.The experimental results show that the across-membrane transport of all the platinum compounds studied follows a first-order kinetic process in the initial stage.The entry of these compounds into the human red blood cell is considered to follow a passive diffusion mechanism.The uptake rate constants of seven platinum(Ⅱ) compounds were determined.The uptake rates are related to the polarity, charge and hydrolysis rate of the coordination compounds.

Key words: Platium compounds, Membrane transport, Kinetics

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ZHANG Wan-Ming, LI Lian-Zhi, LI Rong-Chang, DOU Pei-Yan, WANG Kui . The Kinetic Studies of Across-Erythrocyte Membrane Transport of Platinium(Ⅱ) Complexes[J]. Chem. J. Chinese Universities, 1993, 14(10): 1351.

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The Kinetic Studies of Across-Erythrocyte Membrane Transport of Platinium(Ⅱ) Complexes

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