Studies on Inclusion Compound of Quercetin with β-Cyclodextrin

Abstract

Abstract: The aim of this study was to improve the solubility of quercetin in aqueous solution. The inclusion compound of quercetin with β-cyclodextrin was obtained by saturated aqueous solution method. The formation of the inclusion compound was confirmed by IR spectroscopy and differential scanning calorimetry. The content of quercetin inclusion was determined by UV. The results indicated that the inclusion compound of quercetin with β- cyclodextrin was formed. The dissolubility of quercetin in inclusion form increased from 2.78 μg/mL to 23.15 μg/mL. The experimental data of inclusion compound fitted well to the molar ratio of 1:1. Through the thermodynamic study we got the constants and Δ_rH_m⁰, Δ_rS_m⁰, Δ_rG_m⁰ of the inclusion at different temperatures.

Key words: Quercetin, β-Cyclodextrin, Inclusion compound, Thermodynamics

CLC Number:

O642.3

TrendMD:

SHAO Wei, WANG Jin-Shan, WANG Chun-Xiang, MI Guang-Tai, WANG Da-Qing . Studies on Inclusion Compound of Quercetin with β-Cyclodextrin[J]. Chem. J. Chinese Universities, 1998, 19(7): 1101.

References

Related Articles 15

[1]	WANG Kun, ZOU Xingli, CAO Zhanmin, LI Chonghe, LU Xionggang. Modified Quasichemical Model for Manifold Short-range Orders in Binary Solutions： Unity of Opposites for the Ordered Pairs [J]. Chem. J. Chinese Universities, 2022, 43(11): 20220391.
[2]	LI Fei, LI Xiaoxuan, LI Yijun, HE Xiwen, CHEN Langxing, ZHANG Yukui. Preparation of Surface Oriented Magnetically Imprinted Polymers and the Selective Recognition of Quercetin [J]. Chem. J. Chinese Universities, 2021, 42(12): 3606.
[3]	YAN Fanyong, SUN Zhonghui, PANG Jiping, JIANG Yingxia, CHEN Yuan. Functionalized Carbon Dots of Benzothiazine Derivatives for Detection of Quercetin in Ginkgo Biloba Tea [J]. Chem. J. Chinese Universities, 2020, 41(8): 1768.
[4]	HE Zijun,XIAO Ming,MA Xiangying,QIU Jiangyuan,XIAO Biyuan,QIN Fanghong,HUANG Zaiyin. Facet and Temperature Effects on Dissolution Thermodynamic Functions of Ag₃PO₄ Microcrystals^† [J]. Chem. J. Chinese Universities, 2019, 40(5): 959.
[5]	XIAO Biyuan,QIU Jiangyuan,QIN Fanghong,WAN Ting,XU Yaqun,NONG Xiaohui,HUANG Zaiyin. Study on Particle Size Effect on Adsorption Thermodynamics and Kinetics of Cubic Nano-Cu₂O ^† [J]. Chem. J. Chinese Universities, 2019, 40(10): 2214.
[6]	QIN Fanghong,QIU Jiangyuan,XIAO Biyuan,MI Yan,HUANG Zaiyin. Investigation into the Thermodynamic Properties of Nano-silver Halides Based on the Principle of Dissolution Thermodynamics^† [J]. Chem. J. Chinese Universities, 2018, 39(10): 2214.
[7]	YANG Yejin,YOU Jinglin,WANG Jian,WANG Min,HE Yingxia,WU Zhidong. In-situ High Temperature Raman Spectroscopic and Decomposition Thermodynamic Study of the Structure of Potassium Hydrogen Sulfate and Its Melt^† [J]. Chem. J. Chinese Universities, 2018, 39(10): 2272.
[8]	MA Changmin, LIU Tingyu, CHANG Qiuxiang, LUO Guoyin. Theoretical Studies on the Intrinsic Defects in ZnO and ZnS Crystal^† [J]. Chem. J. Chinese Universities, 2016, 37(5): 932.
[9]	LIU Zuojiao, FAN Gaochao, HE Liangming, DIAO Kaisheng, HUANG Zaiyin, TAN Xuecai. Temperature and Morphology Effect on Surface Thermodynamic Functions of Ag₃PO₄ Microcrystals^† [J]. Chem. J. Chinese Universities, 2015, 36(7): 1385.
[10]	WANG Xiaowen, LI Shuang, JIANG Xiaonan, WANG Changsheng. Site-preference of Quercetin Hydrogen Bonding to Adenine^† [J]. Chem. J. Chinese Universities, 2015, 36(5): 932.
[11]	LIU Zuojiao, FAN Gaochao, LI Xingxing, TAN Xuecai, ZHONG Lianyun, HUANG Zaiyin. Thermodynamic and Kinetic Parameters of in-situ Photocatalytic Process with Different Morphologies of Ag₃PO₄ and Their Free Energy^† [J]. Chem. J. Chinese Universities, 2015, 36(2): 212.
[12]	TURSON Mamat, DAWUT Gulbahar, EMIN Risalat, CHU Ganghui, JELIL Mahmutjan, TURHON Muhetar. Preparation of Quercetin Imprinted Polymer by Living Radical Polymerization and Its Application in the Composition Analysis of Zukamu Granules for Uighur Medicine^† [J]. Chem. J. Chinese Universities, 2015, 36(12): 2402.
[13]	FAN Gaochao, MA Zhao, HUANG Zaiyin, TAN Xuecai, YAO Xianchao. Surface Thermodynamic Properties of Micro/nano Peanut-shaped CaMo $O 4 †$ [J]. Chem. J. Chinese Universities, 2014, 35(5): 1007.
[14]	LIU Xiaoxia, DENG Hao, WANG Yanying, LU Zhiwei, ZENG Xianyin, WANG Xianxiang, ZOU Ping, RAO Hanbing. Thermodynamics Studies on the BSA Adsorption onto Zinc Oxide Surfaces with Different Morphologies^† [J]. Chem. J. Chinese Universities, 2014, 35(10): 2156.
[15]	LI Zhen-Quan, HU Chun-Xiu, CHENG Yu-Qiao, XU Hui, CAO Xu-Long, SONG Xin-Wang, ZHANG Heng-Yi, LIU Yu. Binding Thermodynamics of p-Sulfonatocalix[4]arene with Quaternary Ammonium Dications [J]. Chem. J. Chinese Universities, 2013, 34(4): 853.