Conformational Studies on 2-(4-Aminocarbonyl-2-thiazoyl)-1,4-anhydro-L-xylitols and Their Fluorine Derivatives

Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (11): 1767.

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Conformational Studies on 2-(4-Aminocarbonyl-2-thiazoyl)-1,4-anhydro-L-xylitols and Their Fluorine Derivatives

ZHANG Hu-Yi¹, ZHANG Liang-Ren¹, MA Ling-Tai¹, ZHANG Li-He¹, CUI Yu-Xin², LIU Xue-Hui²

1. Research Group of Antitumor Drugs, School of Phamaceutical Sciences;
2. National Research Laboratory of Natural and Biommetic Drugs, Beijing Medical University, Beijing, 100083

Received:1997-12-13 Online:1998-11-24 Published:1998-11-24

Abstract

Abstract: Employing computer aided molecule simulation, the conformations of 2-(4-aminocarbonyl-2-thiazoyl)-1,4-anhydro Lxylitols and their fluorine derivatives have been studied. The results obtained from calculation show that these novel isomeric Cnucleosides favor the Sconformation. NMRstudy and crystal X-ray analysis of these compounds coincidentally point to Stype furanose conformation.

Key words: Conformation, Computer-aided molecule simulation, NMR, Crystal X-ray analysis, iso-C-nuleosides

CLC Number:

O626

TrendMD:

ZHANG Hu-Yi, ZHANG Liang-Ren, MA Ling-Tai, ZHANG Li-He, CUI Yu-Xin, LIU Xue-Hui . Conformational Studies on 2-(4-Aminocarbonyl-2-thiazoyl)-1,4-anhydro-L-xylitols and Their Fluorine Derivatives[J]. Chem. J. Chinese Universities, 1998, 19(11): 1767.

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Conformational Studies on 2-(4-Aminocarbonyl-2-thiazoyl)-1,4-anhydro-L-xylitols and Their Fluorine Derivatives

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