Investigation of the Interaction Between Nystatin and Solid-supported Phospholipid Membranes

Chem. J. Chinese Universities

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Investigation of the Interaction Between Nystatin and Solid-supported Phospholipid Membranes

WANG Qing^1,2,3,4, YANG Xiao-Hai^1,2,3,4, WANG Hong^1,2,4, WANG Ke-Min^1,2,3,4*

1. State Key Laboratory of Chemo/Biosensing and Chemometrics,
2. College of Chemistry and Chemical Engineering,
3. Biomedical Engineering Center,
4. Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China

Received:2007-04-03 Revised:1900-01-01 Online:2007-11-10 Published:2007-11-10
Contact: WANG Ke-Min

Abstract

Abstract: Nystatin is a polyene antifurgal drug to which many molds and yeasts are sersitive, including cryptococcus neoformans, candida, aspergillus, etc. To realize the mechanism of nystatin more particularly, the techniques of SPR and impedance were used to investigate the interaction between nystatin and two kinds of solid-supported phospholipid membranes. The results show that nystatin could interact with pure phospholipid membranes, whether they are monolayer or bilayer. In addition, impedance spectra show that ion channels may be formed when nystatin interacted with phospholipid membranes.

Key words: Surface plasmon resonance, A.C. impedance, Solid-supported phospholipid membrane, Nystatin

CLC Number:

O657.39

TrendMD:

WANG Qing^1,2,3,4, YANG Xiao-Hai^1,2,3,4, WANG Hong^1,2,4, WANG Ke-Min^1,2,3,4*. Investigation of the Interaction Between Nystatin and Solid-supported Phospholipid Membranes[J]. Chem. J. Chinese Universities, doi: .

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Investigation of the Interaction Between Nystatin and Solid-supported Phospholipid Membranes

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