Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (5): 736.

• Articles • Previous Articles     Next Articles

Synthesis of Some Antagonists of PAF of MK 287's Kind

LIN Hui1, SHI Hong-Xin2, MandvillG.3   

  1. 1. Central Laboratory of Biochemistry & Physiological Sciences, Hubin Campus, Zhejiang University, Hangzhou, 310006;
    2. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014;
    3. Lab.des Carbocycles, I.C.M.O.Universite de Paris-Sud, 91405, Orsay Cedex, France
  • Online:1999-05-24 Published:1999-05-24

Abstract: Trans 2,5-diaryltetrahydrofuran is a potent antagonist of platelet activating factor. It is obtained in high stereoselectivity by the reactions of arylation, oxidation, arylation, cyclization, hot decomposition and hydrogenation starting from (±)4,10-dioxatricyclo[5,2,1,02,6]-dec-8-ene-3-ole and PhTi(OPr-i)3.

Key words: Synthesis, Stereoselectivity, Chiral, Diaryltetrahydrofuran

CLC Number: 

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