Studies on Electrospray Mass Spectrometry of Some Narcotic Drugs

Abstract

Abstract: Using electrospray ionization(ESI) and tandem mass spectrometry techniques, the protonic positions in protonated molecular ions of some narcotic drugs were studied. The data of ESI/MSⁿexperiments of morphine and deuterium-loaded morphine were first discussed. The protonic position was considered to locate on oxygen atom of cyclic ether in morphine molecular. Compared with the same and different ions among morphine, codeine, acetylcodeine and dihydrocodeine, the protonic positions in protonated molecular ions of these compounds were further determined. The fragmentation mechanism of morphine in ESI/MSⁿexperiments was also repored in the paper, and there were similar dehydrolysis mechanism in gas phase or in liquid phase for morphine.

Key words: Electrospray ionization, Tandem mass spectrometry, Narcotic drugs

CLC Number:

O657.6

TrendMD:

SONG Feng-Rui, LIU Zhi-Qiang, SUN Wei-Xing, LIU Shu-Ying, HUANG Hai-Wei . Studies on Electrospray Mass Spectrometry of Some Narcotic Drugs[J]. Chem. J. Chinese Universities, 1999, 20(4): 558.

[1]	ZHU Kai, LI Jie, WU Xiaoyi, HU Weiwei, WU Dongmei, YU Chengxiao, GE Zhiwei, YE Xingqian, CHEN Shiguo. Combined PGC-Triple-Tof-MS Enables the Separation， Identification of Sugar Beet Pectin Derived Oligomers [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220023.
[2]	DENG Jiewei, YANG Yunyun, LIN Li, LUAN Tiangang. Rapid Classification of Daphniamagna and Daphnia pulex by Surface-coated Probe Nanoelectrospray Ionization Mass Spectrometry Lipidomics [J]. Chem. J. Chinese Universities, 2020, 41(9): 2011.
[3]	LI Xiaoqian, ZHANG Hua, LU Haijian, LIU Chang, LIU Qinglong, MA Xiayu, FANG Yuanping, LIANG Dapeng. Mechanism of Photocatalytic Degradation of Rhodamine B by TiO₂ Nanowire Array with Internal Extraction Electrospray Ionization Mass Spectrometry [J]. Chem. J. Chinese Universities, 2020, 41(9): 2003.
[4]	WANG Xiaoqun, HUANG Guangming. Investigation of Lipid Distributions by Trifluoroacetic Acid-enhanced Desorption Electrospray Ionization Mass Spectrometry Imaging [J]. Chem. J. Chinese Universities, 2020, 41(12): 2673.
[5]	YANG Xiaotian,GENG Zhibin,KUANG Siliang,FENG Shouhua. FeNi(OH)_x Thin Films Prepared by Electrospray Ionization for Electrocatalytic Water Oxidation ^† [J]. Chem. J. Chinese Universities, 2020, 41(1): 56.
[6]	LI Cheng,WANG Chengjian,JIN Wanjun,HAN Jianli,YANG Meifang,GAO Xi,HUANG Linjuan,WANG Zhongfu. Mass Spectrometric Analysis of N-Glycans of Glycoprotein Separated by SDS-PAGE Gel from Ginkgo Seed^† [J]. Chem. J. Chinese Universities, 2019, 40(1): 69.
[7]	WU Fangling,CHU Yanqiu,CHEN Xin,WEI Wanghui,DING Chuanfan. Critical Factors Affecting Noncovalent Interaction Between Pentapeptides Explored by Electrospray Ionization Mass Spectrometry^† [J]. Chem. J. Chinese Universities, 2018, 39(9): 1927.
[8]	KE Mufang, HAN Jing, ZHU Tenggao, LIU Wenjie, ZHANG Hua, KOU Wei, LIANG Dapeng. Direct and Rapid Analysis of Avocado Using Internal Extractive Electrospray Ionization Mass Spectrometry^† [J]. Chem. J. Chinese Universities, 2017, 38(5): 738.
[9]	HUANG Lei, LI Xue, XU Meng, HUANG Zhengxu, ZHOU Zhen. Identification of Relatively High Molecular Weight Compounds in Human Breath Using Secondary Nano Electrospray Ionization Ultrahigh Resolution Mass Spectrometry^† [J]. Chem. J. Chinese Universities, 2017, 38(5): 752.
[10]	HUANG Yandong, WU Ruofei, CHU Yanqiu, DING Chuanfan. Effect of Side Chain of α-Amino Acids and Esters on the Stability Constants for β-Cyclodextrin Complexes^† [J]. Chem. J. Chinese Universities, 2017, 38(5): 743.
[11]	PENG Yifang, WANG Chengjian, WANG Jingjing, LI Lingmei, JIN Wanjun, QIANG Shan, SHI Hongdan, ZHANG Ying, HUANG Linjuan, WANG Zhongfu. Analysis of Antigenic Determinant Glycans of Peanut Allergy Glycoprotein Ara h1 by Mass Spectrometry^† [J]. Chem. J. Chinese Universities, 2016, 37(9): 1622.
[12]	DENG Min,FANG Xiaowei,GUO Xiali,HUANG Xueyong,LIU Xingxing,YU Tenghui,LUO Liping. Direct Detection of Tetracycline in Honey by Neutral Desorption-Extractive Electrospray Ionization Mass Spectrometry^† [J]. Chem. J. Chinese Universities, 2016, 37(8): 1430.
[13]	LI Penghui, DENG Lingli, LUO Jiao, LI Wei, NING Jing, DING Jianhua, WU Xiaoping. EESI-MS Detection and Statistical Analysis of Multi-batch of Exhaled Breath Metabolomics Data of Liver Failure Patients [J]. Chem. J. Chinese Universities, 2016, 37(4): 626.
[14]	WU Ruofei, CHU Yanqiu, XU Chongsheng, LIU Zhipan, DING Chuanfan. Fragmentation Reaction of Complexes of Alkali Metal Cations with Tripeptides in Gas Phase^† [J]. Chem. J. Chinese Universities, 2016, 37(12): 2150.
[15]	CHEN Huanhuan, ZHAO Xia, LUAN Xiaohong, YU Guangli. Application of Electrospray Tandem Mass Spectrometry in Sequence Analysis of Oligosaccharides^† [J]. Chem. J. Chinese Universities, 2015, 36(1): 1.

Studies on Electrospray Mass Spectrometry of Some Narcotic Drugs

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments