Studies on the Interaction of Et2SnCl2 with DNA

Abstract

Abstract: In this paper, the spectrophotometric, cyclic voltammetric methods and viscosity determination were used to study the interaction of the anti tumor active Et₂SnCl₂ with DNA. The results indicate that Et₂SnCl₂ mainly reacts electrostatically with the phosphate backbone of DNA, leading to an increase of the relative viscosity of DNAand the occurring of hypochromism of DNA. No hyperchromism was observed during the whole reaction process. The molecular action mechanism of Et₂SnCl₂ with DNAwas proposed.

Key words: Antitumor, Et₂SnCl₂, DNA

CLC Number:

O627.42
R979.1

TrendMD:

LI Qing-Shan, LIU Rui-Ling, HUANG Ji-Jun, YANG Pin. Studies on the Interaction of Et₂SnCl₂ with DNA[J]. Chem. J. Chinese Universities, 2000, 21(4): 513.

[1]	LIU Suyu, DING Fei, LI Qian, FAN Chunhai, FENG Jing. Azobenzene-integrated DNA Nanomachine [J]. Chem. J. Chinese Universities, 2022, 43(8): 20220122.
[2]	WU Yushuai, SHANG Yingxu, JIANG Qiao, DING Baoquan. Research Progress of Controllable Self-assembled DNA Origami Structure as Drug Carrier [J]. Chem. J. Chinese Universities, 2022, 43(8): 20220179.
[3]	WANG Junyang, LIU Zheng, ZHANG Qian, SUN Chunyan, LI Hongxia. Application of DNA Silver Nanoclusters in the Fluorescence Biosensors based on Functional Nucleic Acids [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220010.
[4]	WU Yangyi, CHEN Jianping, Ai Yijing, WANG Qingxiang, GAO Fei, GAO Feng. Synthesis of 2-（2-Hydroxy-3-methoxyphenyl）-C₆₀ and Its Application for Sensing of Cauliflower Mosaic Virus 35S Promotor [J]. Chem. J. Chinese Universities, 2021, 42(6): 1754.
[5]	YANG Xinjie, LAI Yanqiong, LI Qiuyang, ZHANG Yanli, WANG Hongbin, PANG Pengfei, YANG Wenrong. An Enzyme-free and Label-free Fluorescent Probe for Detection of Microcystin-LR Based on Circular DNA-Silver Nanoclusters [J]. Chem. J. Chinese Universities, 2021, 42(12): 3600.
[6]	LIU Xuejiao, YANG Fan, LIU Shuang, ZHANG Chunjuan, LIU Qiaoling. Progress in Aptamer-targeted Membrane Protein Recognition and Functional Regulation [J]. Chem. J. Chinese Universities, 2021, 42(11): 3277.
[7]	HU Ling, YIN Yao, KE Guoliang, ZHANG Xiaobing. Regulation of Cell-cell Interactions Based on DNA Nanostructures [J]. Chem. J. Chinese Universities, 2021, 42(11): 3284.
[8]	MAO Yu, QU Hao, ZHENG Lei. Research Progress on RNA⁃cleaving DNAzyme for the Detection of Pathogenic Bacteria [J]. Chem. J. Chinese Universities, 2021, 42(11): 3445.
[9]	PENG Huo, GAO Zehang, LIAO Chengyue, WANG Xiaodong, ZHOU Hongbo, ZHAO Jianlong. Robust Droplet Digital PCR Chip for Absolute Quantitative Detection of Nucleic Acid [J]. Chem. J. Chinese Universities, 2020, 41(8): 1760.
[10]	REN Yushuang, GUO Yuanyuan, LIU Xueyi, SONG Jie, ZHANG Chuan. Platinum(Ⅳ) Prodrug-grafted Phosphorothioate DNA and Its Self-assembled Nanostructure for Targeted Drug Delivery [J]. Chem. J. Chinese Universities, 2020, 41(8): 1721.
[11]	YAN Lei, MAO Xiuhai, ZUO Xiaolei. Biomimicry of Cellular Membrane with Framework Nucleic Acids^† [J]. Chem. J. Chinese Universities, 2020, 41(7): 1415.
[12]	ZHANG Kaixiang, LIU Junjie, SONG Qiaoli, WANG Danyu, SHI Jinjin, ZHANG Haiyue, LI Jinghong. Multifunctional DNA Nanoflowers for Autophagy Inhibition and Enhanced Antitumor Chemotherapy^† [J]. Chem. J. Chinese Universities, 2020, 41(7): 1461.
[13]	ZHANG Luhao, CAO Shuting, LIU Jiangbo, ZUO Xiaolei, WANG Lihua, FAN Chunhai, LI Jiang. Construction of Controllable Lipid-DNA Complex for Study in Membrane Biology ^† [J]. Chem. J. Chinese Universities, 2020, 41(6): 1151.
[14]	BAI Bing,WANG Long,XU Gaigai,YANG Pengfei,ZHANG Gaihong,MAO Duobin. Synthesis and Antitumor Activities of α-2,7,11-Cembratriene-4,6-diol Derivatives ^† [J]. Chem. J. Chinese Universities, 2020, 41(3): 481.
[15]	LI Xianming, ZHENG Ting, GAO Lu, LI Feng, HOU Xiandeng, WU Peng. Recombinase Polymerase Amplification： from Principle to Performance [J]. Chem. J. Chinese Universities, 2020, 41(12): 2587.

Studies on the Interaction of Et₂SnCl₂ with DNA

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments