Measurement of Oil-Water Partition Coefficients by Improved Microemulsion Electrokinetic Chromatography

Chem. J. Chinese Universities

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Measurement of Oil-Water Partition Coefficients by Improved Microemulsion Electrokinetic Chromatography

JIANG Xue-Mei^1,2, WEI Wei-Li¹, JIANG Jun-Po¹, SHI Kai-Yun², MU Xiao-Jing¹, CHEN Zhi-Tao², XIA Zhi-Ning^1,2

1. Department of Pharmaceutics, Institute of Chemistry and Chemical Engineering,
2. Key Laboratory for Biomechanics and Tissue Engineering, Ministry of Education, Chongqing University, Chongqinq 400044, China

Received:2005-12-15 Revised:1900-01-01 Online:2006-08-10 Published:2006-08-10
Contact: XIA Zhi-Ning

Abstract

Abstract: Microemulsion electrokinetic chromatography(MEEKC) was used as a powerful method for the indirect measurement of oil-water partition coefficients of organic compounds. Considering the problems of determining oil-water partition coefficients by conventional MEEKC, the concentration of solute and high electric-field having impact on the migration behavior of compound was studied, the reason and mechanism of which were also studied. Moreover, an improved method of MEEKC(I-MEEKC) that can be used to solve the problems found was developed. Applying this improved method to determining oil-water partition coefficients for compounds, such as alkyl-benzene: benzene, toluene and ethyl benzene, good result was obtained: the average error between oil-water partition coefficients estimated by using improved MEEKC and literature values published was 0.07 logarithm units. In this work not only a new method was established to measure oil-water partition coefficients with MEEKC, but also the improved MEEKC is developed further and become more reliable and more accurate method for qualitative analysis.

Key words: MEEKC, Improved method, Oil-water partition coefficients, High electric-field

CLC Number:

O657

TrendMD:

JIANG Xue-Mei^1,2, WEI Wei-Li¹, JIANG Jun-Po¹, SHI Kai-Yun², MU Xiao-Jing¹, CHEN Zhi-Tao², XIA Zhi-Ning^1,2. Measurement of Oil-Water Partition Coefficients by Improved Microemulsion Electrokinetic Chromatography[J]. Chem. J. Chinese Universities, doi: .

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Measurement of Oil-Water Partition Coefficients by Improved Microemulsion Electrokinetic Chromatography

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