Preparation of Poly(3-acrylamidophenylboronic Acid-co-N,N-dime-thylacrylamide-co-acrylamide)hydrogels and Investigations on Their Sugar-sensitive Properties

Chem. J. Chinese Universities

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Preparation of Poly(3-acrylamidophenylboronic Acid-co-N,N-dime-thylacrylamide-co-acrylamide)hydrogels and Investigations on Their Sugar-sensitive Properties

LI Bo, TENG Da-Yong, WANG Zhen, LI Chao-Xing

The Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China

Received:2006-04-17 Revised:1900-01-01 Online:2007-02-10 Published:2007-02-10
Contact: LI Chao-Xing

Abstract

Abstract: Glucose-sensitive porous poly(3-acrylamidophenylboronic acid-co-N,N-dimethylacrylamide-co-acrylamide)[P(AAPBA-co-DMAA-co-AAm)]hydrogels were prepared by radical copolymerization in dimethyl sulphoxide(DMSO) solution. At Physiological pH condition(pH 7.4, 37 ℃), the sensitivity of the Hdro gels to the sugar-concentration was investigated, and the influence of the component on the swelling ratio was studied at the same time. At the given range, with the increase of the contents of AAPBA and AAm in the gels. Compared with conventional biblock polymer, this hydrogel preserved an excellent sensibility to sugar-concentration and could response when the mass concentration of glucose is above 200 mg/dL, which approaches to diabetic's threshold of blood sugar. The swelling ratio of this hydrogel reached more than 10 times. At the same time, the response time to concentration of glucose decreased to 2—3 h. The results of surging experiment show the porous hydrogel possesses an excellent stimulate-response capability to sugar. Therefore, these novel porous Hdrogels have potential for the controlled release of drugs, especially for the micro molecular drugs.

Key words: Phenylboronic acid, Sugar-sensitivity, Gel, Swelling, Responsivity

CLC Number:

O631

TrendMD:

LI Bo, TENG Da-Yong, WANG Zhen, LI Chao-Xing. Preparation of Poly(3-acrylamidophenylboronic Acid-co-N,N-dime-thylacrylamide-co-acrylamide)hydrogels and Investigations on Their Sugar-sensitive Properties[J]. Chem. J. Chinese Universities, doi: .

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Preparation of Poly(3-acrylamidophenylboronic Acid-co-N,N-dime-thylacrylamide-co-acrylamide)hydrogels and Investigations on Their Sugar-sensitive Properties

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