Shape-memory and Biocompatibility Properties of Segmented Polyurethanes Based on Poly(L-lactide)

Chem. J. Chinese Universities

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Shape-memory and Biocompatibility Properties of Segmented Polyurethanes Based on Poly(L-lactide)

PING Peng^1,2, WANG Wen-Shou^1,2, Zhang Pei-Biao¹, CHEN Xue-Si¹, JING Xia-Bin¹

1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2. Graduate School of Chinese Academy of Sciences, Beijing 100039, China

Received:2006-06-05 Revised:1900-01-01 Online:2007-02-10 Published:2007-02-10
Contact: JING Xia-Bin

Abstract

Abstract: A series of segmented poly(L-lactide)-polyurethanes(PLA-PU) were synthesized by a two-step method, with oligo-poly(L-lactide)(PLA) as the soft segments and the reaction product of 2,4-toluene diisocyanate(TDI) and ethylene glycol(EG) as the hard segments. The shape memory properties of PLA-PUs were examined. The processed PLA-PUs could recover almost 100% to their original shape within 10 ℃ from the lowest recovery temperature. In the recovery process, the PLA-PUs showed a maximum contracting stress of shape change in the range of 1.5—4 MPa depending on the PLA segmental length and the hard-segmental content and higher than that of poly(ε-caprolactone polyurethane)(PCL-PU). Besides, the influence of deforming and fixing temperatures on shape memory properties of PLA-PU was studied in detail. They could affect not only the recovery temperature but also the maximum contracting stress. The experiments of cell incubation were used to evaluate the biocompatibility of PLA-PU. The results show that the biocompatibility of PLA-PU is comparable to that of the pure PLA.This kind of polyurethane can be used as implanted medical devices with a shape memory property.

Key words: Polyurethane, Poly(L-lactide), Shape memory, Biocompatibility

CLC Number:

O631

TrendMD:

PING Peng^1,2, WANG Wen-Shou^1,2, Zhang Pei-Biao¹, CHEN Xue-Si¹, JING Xia-Bin¹. Shape-memory and Biocompatibility Properties of Segmented Polyurethanes Based on Poly(L-lactide)[J]. Chem. J. Chinese Universities, doi: .

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Shape-memory and Biocompatibility Properties of Segmented Polyurethanes Based on Poly(L-lactide)

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