Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (3): 437.

• Reviews • Previous Articles     Next Articles

Oxidative DNA Cleavage Mediated by Copper Complexes

SUN Hui, YU Zhen, YANG Wei-Qi, HE Wei-Jiang*, GUO Zi-Jian*   

  1. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
  • Received:2010-11-22 Revised:2011-01-05 Online:2011-03-10 Published:2011-02-23
  • Contact: HE Wei-Jiang;GUO Zi-Jian E-mail:heweij69@nju.edu.cn
  • Supported by:

    国家自然科学基金(批准号: 20871066, 10979019, 21021062)和江苏省自然科学基金(批准号: BK2008015, BK2009229)资助.

Abstract: In this review, the mechanism of the oxidative DNA cleavage promoted by copper complexes was discussed at first according to the DNA binding ability/mode, the reactive oxygen species (ROS) formation and the subsequent ROS-induced DNA damage. Combined with our works in this field, the complex nuclear number,metal centers,steric effect,charge,redox potential were investigated to clarify the the structral effects of copper complexes on their DNA cleaving behavior.In addition, the photo-induced DNA cleavage by copper complexes has also been surveied briefly. Finally, the different strategies for the specific DNA cleavage mediated by copper complexes were reviewed. All these should be helpful for the future design of copper-containing artificial nuclease of higher efficiency and specificity.

Key words: copper, DNA, oxidative cleavage, specificity, photo-induced cleavage

TrendMD: