Hepatic-targeting Microcapsules Construction by Layer-by-layer Self-assembly of Lactose-branched Polyelectrolyte

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (4): 957.

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Hepatic-targeting Microcapsules Construction by Layer-by-layer Self-assembly of Lactose-branched Polyelectrolyte

GAO Xia, ZHANG Fu, CHEN Zhi-Chun, LIN Xian-Fu

Department of Chemistry, Zhejiang University, Hangzhou 310027, China

Received:2010-07-23 Revised:2010-09-13 Online:2011-04-10 Published:2011-03-09
Contact: LIN Xian-Fu E-mail:llc123@zju.edu.cn
Supported by:
国家自然科学基金(批准号: 20874086)资助.

Abstract

Abstract: Hepatic-targeting microcapsules were constructed by Layer-by-layer self-assembly of poly(allylamine hydrochloride) (PAH) and chemo-enzymatic synthesized poly(vinyl lactose ester-co-sodium p-styrenesulfonate) (PLESS) containing lactose branches. Alternate deposition of PAH and PLESS was carried out on different solid surfaces such as quartz slides and CaCO3 microparticles. The self-assembly nature of the novel polyelectrolytes was investigated in detail by varying polyelectrolytes concentration, ionic strength, and counteranion types. The assembly process and structure of multilayers were characterized by UV-vis. Hollow capsules were formed after the removal of CaCO3 templates and observed by TEM. The potential targetability of the system was proved in vitro by PNA lectin recognition. Furthermore biocompatibility of the polyelectrolytes was tested by MTT assay.

Key words: Lactose, Layer-by-layer Self-Assembly, Microcapsules, Hepatic targeting, Biocompatibility

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GAO Xia, ZHANG Fu, CHEN Zhi-Chun, LIN Xian-Fu. Hepatic-targeting Microcapsules Construction by Layer-by-layer Self-assembly of Lactose-branched Polyelectrolyte[J]. Chem. J. Chinese Universities, 2011, 32(4): 957.

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Hepatic-targeting Microcapsules Construction by Layer-by-layer Self-assembly of Lactose-branched Polyelectrolyte

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