Preparation and Application of Self-assembly of Amphiphilic Cyclotriphosphazene†

doi:10.7503/cjcu20140063

Abstract

Abstract:

A novel amphiphilic cyclotriphosphazene derivative was synthesized and its properties including chemical composition, crystalline state, thermostability and micromorphology were systematically characterized by FTIR, DSC and SEM. Meanwhile, the cytotoxicity of the compound was also tested. The special micro-structure with abundant ducts based on the long hydrophilic chain PEG was formed by the cyclotriphosphazene derivative via a self-assembled process, these ducts could be utilized as vehicles for loading curcumin and magnetic Fe₃O₄ nanoparticles. Furthermore, the micromorphology, crystalline state, thermostability and magnetite properties of the fabricated drug delivery system were thoroughly investigated and the drug-loaded mechanism was revealed.

Key words: Amphiphilic cyclotriphosphazene, Self-assembly, Curcumin, Magnetism

CLC Number:

O627

TrendMD:

LI Xiaoli, LI Zhiguo, LI Bin, REN Yuting. Preparation and Application of Self-assembly of Amphiphilic Cyclotriphosphazene^†[J]. Chem. J. Chinese Universities, 2014, 35(8): 1675.

Figures/Tables 9

Scheme 1 Synthetic route of MMPCP

Table 1 FTIR spectrum data of MMPCP

$ν ˙$ /cm^-1	Functional group	$ν ˙$ /cm^-1	Functional group
1270, 1208	$γ (PN, P — N)$	3067	γ_(C—H)(Benzene)
3332	γ_(N—H)(2° Amide)	2874	γ_(C—H)(MPEG)
1537	δ_(N—H)(trans, 2° Amide)	1600, 1501	γ_(C—H)(Benzene)
1651	$γ (CO)$ (Amide)	952	γ_(P—O—Ar)
1731, 1716	$γ (CO)$ (Ester)	1105	γ_(O—C)(MPEG)

Table 1 FTIR spectrum data of MMPCP

$ν ˙$ /cm^-1	Functional group	$ν ˙$ /cm^-1	Functional group
1270, 1208	$γ (PN, P — N)$	3067	γ_(C—H)(Benzene)
3332	γ_(N—H)(2° Amide)	2874	γ_(C—H)(MPEG)
1537	δ_(N—H)(trans, 2° Amide)	1600, 1501	γ_(C—H)(Benzene)
1651	$γ (CO)$ (Amide)	952	γ_(P—O—Ar)
1731, 1716	$γ (CO)$ (Ester)	1105	γ_(O—C)(MPEG)

Fig.1 Micrographs of 293 cells after incubation for 24 h in the presence of MMPCP

Fig.2 Different multiple SEM images of MMPCP

Fig.3 SEM images of MC

Fig.4 TEM images of MC(A) and MMC system(B)

Fig.5 DSC curves of MMPCP-Cur system

Fig.6 TGA curves of MMPCP-Cur system

Fig.7 Schematic illustration of MMC with a sheet crystal structure formed by self-assembly

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