Synthesis, Characterization and Drug Release of Temperature-sensitive PLGA-PEG-PLGA Hydrogel

Chem. J. Chinese Universities

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Synthesis, Characterization and Drug Release of Temperature-sensitive PLGA-PEG-PLGA Hydrogel

LIN Hao^1,2; TIAN Hua-Yu^1,2; SUN Jing-Ru^1,2; ZHUANG Xiu-Li^1,2; CHEN Xue-Si^1*; LI Yue-Sheng¹; JING Xia-Bin¹

1. State Key Laboratory of Polymer Chemistry and Physics, Changchun
Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun
130022, China;
2. Graduate School of Chinese Academy of Sciences, Beijing 100039, China

Received:2005-10-19 Revised:1900-01-01 Online:2006-07-10 Published:2006-07-10
Contact: CHEN Xue-Si

Abstract

Abstract: A series of PLGA-PEG-PLGAs with Mn=3000—7000 were synthesized by ROP of L-lactide and glycolide with PEG(Mw=1000 and 4600) as the initiators. The dynamic viscoanalyser and phase diagram were utilized to investigate the mechanical properties with sol-gel transition of the hydrogel system, and the G' and G″were between 102 and 104 Pa. Also, the fluorescence spectroscopy of PLGA-PEG-PLGA micelle solution was investigated to reveal the gelation mechanism of hydrogel. Finally, the controlled release of ceftazidime from the hydrogel was observed.

Key words: PEG, PLGA, Hydrogel, Temperature-sensitivity, Mechanical property, Drug release

CLC Number:

O631

TrendMD:

LIN Hao^1,2; TIAN Hua-Yu^1,2; SUN Jing-Ru^1,2; ZHUANG Xiu-Li^1,2; CHEN Xue-Si^1*; LI Yue-Sheng¹; JING Xia-Bin¹

. Synthesis, Characterization and Drug Release of Temperature-sensitive PLGA-PEG-PLGA Hydrogel [J]. Chem. J. Chinese Universities, doi: .

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Synthesis, Characterization and Drug Release of Temperature-sensitive PLGA-PEG-PLGA Hydrogel

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