Preparation of Poly(L-lactide)/Surface-Grafting Silica Nanocomposites and Their Surface Induction of Bone-like Apatite in Simulated Body Fluid

Chem. J. Chinese Universities

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Preparation of Poly(L-lactide)/Surface-Grafting Silica Nanocomposites and Their Surface Induction of Bone-like Apatite in Simulated Body Fluid

YANG Yan¹, YAN Shi-Feng¹, LI Xiao-Xiu¹, YIN Jing-Bo^1*, CHEN Xue-Si^2*

1. Department of Polymer Materials, Shanghai University, Shanghai 201800, China;
2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received:2008-06-17 Revised:1900-01-01 Online:2008-11-10 Published:2008-11-10
Contact: YIN Jing-Bo,CHEN Xue-Si

Abstract

Abstract: In order to improve the dispersibility of nano-silica(SiO₂) in the matrix of poly(L-lactide)(PLLA), the silica nanoparticles were surface-grafted with L-lactic acid oligomer. The surface-grafting reaction is confirmed via IR, ²⁹Si MAS NMR and TGA analyses. The nanocomposites of surface-grafting silica(g-SiO₂) with PLLA prepared through solvent-cast technique were immersed in simulated body fluid(SBF) to examine their bioactivity. Its apatite-forming ability was characterized by means of X-ray diffraction(XRD), Fourier transform infrared(FTIR) spectra, scanning electron microscopy(SEM) and energy-dispersive spectrometer(EDS). The results show that L-lactic acid oligomer can be successfully grafted onto silica surface. The highest grafting amounts of L-lactic acid are 9.22% when the reaction time is 36 h. With the increase of filler content and soaking time, the amorphous surface coating is transformed into carbonated hydroxyapatite(CHA), the molar ratio of Ca to P is about 1.72, close to that of apatite. This kind of nanocomposites could be one of the best potential bioactive materials for bones substitute or as a tissue engineering scaffold.

Key words: Simulated body fluid, Composite material, Polylactide, Silica, Surface grafting, Bone-like apatite

CLC Number:

O631

TrendMD:

YANG Yan¹, YAN Shi-Feng¹, LI Xiao-Xiu¹, YIN Jing-Bo^1*, CHEN Xue-Si^2*. Preparation of Poly(L-lactide)/Surface-Grafting Silica Nanocomposites and Their Surface Induction of Bone-like Apatite in Simulated Body Fluid[J]. Chem. J. Chinese Universities, doi: .

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Preparation of Poly(L-lactide)/Surface-Grafting Silica Nanocomposites and Their Surface Induction of Bone-like Apatite in Simulated Body Fluid

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