Synthesis, Characterization and PTP1B Inhibitory Activity of the Vanadium Complexes with Amino-acids

doi:10.3969/j.issn.0251-0790.2012.02.006

Abstract

Abstract: Two vanadium-amino acid-hydroxylamido complexes,[VO(NH₂O)₂(C₅H₁₀O₂N] (1) and K[VO(NH₂O)₂(C₆H₁₂NO₂N]₂Cl·H₂O(2) were synthesized. Their structures and components were characterized by elemental analysis, IR spectrometry, UV-Vis spectrometry, thermal analysis and X-ray single crystal diffraction and their PTP1B inhibitory activities were also explored. Complexes 1 and 2 both crystallize in triclinic system with space group P1. The central vanadium and seven coordinated atoms form a distorted pentagonal bipyramidal. Two O atoms and three N atoms from hydroxylamine and amino-acids define an equatorial plane approximately perpendicular to V＝O. The N of hydroxylamine is cis to N of amino-acids and the O of amino-acids is trans to V＝O. Complex 2 displays a good inhibitory activity against PTP1B(inhibition rate is 90.51% at 20 μg/mL).

Key words: Vanadium-amino acid-hydroxylamido complex, Crystal structure, PTP1B inhibitory activity

CLC Number:

O614.5

TrendMD:

ZHANG Heng-Qiang, ZHANG Qi-Ying, LI Jia, LIU Dong, WU Xiao-Fang, SHAN Yong-Kui. Synthesis, Characterization and PTP1B Inhibitory Activity of the Vanadium Complexes with Amino-acids[J]. Chem. J. Chinese Universities, 2012, 33(02): 243.

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