Preparation, Release-control and Cell Apoptosis of Liver Cancer in the Tea Polyphenol Manganese Loaded on a Chitosan Microparticles

Chem. J. Chinese Universities

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Preparation, Release-control and Cell Apoptosis of Liver Cancer in the Tea Polyphenol Manganese Loaded on a Chitosan Microparticles

HUANG He-Ning^1,2, LI Cheng¹, XIE Li-Sheng¹, HUANG He-Qing^1,3*

1. The Key Laboratory of MOE for Cell Biology and Tumor Cell Engineering of Ministry of Education, School of Life Sciences, Xiamen University, Xiamen 361005, China;
2. Department of Chemical and Biological Engineering, College of Sanming, Sanming 365004, China;
3. State Key Laboratory of Physical Chemistry of Solid Surface, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry & Chemical Engineering, Xiamen University, Xiamen 361005, China

Received:2007-08-07 Revised:1900-01-01 Online:2008-08-10 Published:2008-08-10
Contact: HUANG He-Qing

Abstract

Abstract: The chitosan as a wrapping material was selected to prepare a microparticles of tea polyphenol manganese-chitosan(TPMn). Fluorescence characteristics of TPMn-chitosan microparticles was revealed by fluorescence microscopy. Size and distribution orderliness of TPMn-chitosan microparticles was further approved by the scanning electron microscopy and the transmission electron microscopy, respectively. The envelopment ratio of TPMn-chitosan microparticles was calculated to be 68% by RE-HPLC approach, which is in accordance with the ratio request of release-controlled drug at the micron level of microparticles. The results of kinetic studies show that two chitosan microparticles loaded on both tea polyphenol(TP) and TPMn, respectively, have capacity for controlling-release TP for exceeding 40 h, but this rate in TP microparticles was somewhat quicker than that of TPMn microparticles. Even so, both miscroparticles have capacity for inducing cells of liver cancer apoptosis, but this apoptosis rate by TPMn-chitosan microparticles was somewhat higher than that by TP-chitosan microparticles. The experimental results prove that the TPMn-chitosan microparticles was propitious to release and control TPMn for enhancing the apoptosis rate of tumour cell induced. TPMn-chitosan microparticles would have a potential for developing a new injecting drug for antitumor.

Key words: TPMn-chitosan microparticles, Characteristics of physical chemistry, Controlling-release, Cell of liver cancer, Apotosis

CLC Number:

O623

TrendMD:

HUANG He-Ning^1,2, LI Cheng¹, XIE Li-Sheng¹, HUANG He-Qing^1,3*. Preparation, Release-control and Cell Apoptosis of Liver Cancer in the Tea Polyphenol Manganese Loaded on a Chitosan Microparticles[J]. Chem. J. Chinese Universities, doi: .

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Preparation, Release-control and Cell Apoptosis of Liver Cancer in the Tea Polyphenol Manganese Loaded on a Chitosan Microparticles

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