Influence of Saikosaponina A on Monoamine Neurotransmitters and the Corresponding Metabolin Compositions in Depressed Rats’ Brain

Chem. J. Chinese Universities

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Influence of Saikosaponina A on Monoamine Neurotransmitters and the Corresponding Metabolin Compositions in Depressed Rats’ Brain

GE Hong-Yan¹, CHEN Bo¹, XU Dan¹, LI You-Tian¹*, LI Yang²

1. First Clinical Hospital, Jinlin University, Changchun 130021, China;
2. Medical Department, Beijing University, Beijing 100083, China

Received:2008-05-19 Revised:1900-01-01 Online:2008-08-10 Published:2008-08-10
Contact: LI You-Tian

Abstract

Abstract: The high performance liquid chromatography was applied to investigate the influence of the chemical composition, saikosaponina A, on monoamine neurotransmitter in the depressed rats’ brain. It is shown from the analytical results that in the depressed rats’ brain, the contents of homovanillic acid, noradrenaline, dihydroxyphenyl ethylamine and 5-HT increase in the presence of the saikosaponin A. These results can help to clarify the mechanism of saikosaponin A in curing the depression.

Key words: Saikosaponina A, High performance liguid chromatography, Depression, Monoamine neurotransmitter

CLC Number:

O657.7

TrendMD:

GE Hong-Yan¹, CHEN Bo¹, XU Dan¹, LI You-Tian¹*, LI Yang². Influence of Saikosaponina A on Monoamine Neurotransmitters and the Corresponding Metabolin Compositions in Depressed Rats’ Brain[J]. Chem. J. Chinese Universities, doi: .

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Influence of Saikosaponina A on Monoamine Neurotransmitters and the Corresponding Metabolin Compositions in Depressed Rats’ Brain

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