Synthesis of Bis(1-Acetyl-4-Aroylthiosemicarbazides) and Their Derivatives

Abstract

Abstract: A series of new bis(1-acetyl-4-aroylthiosemicarbazides) Ⅱ were synthesized by condensation of aroylisothiocyanates with succinylhydrazine Ⅰ in acetonitrileSome bis(3-methenyl-4-aroyl-l,2,4-triazoline-5-thiones) Ⅲ were obtained in good yields (42.7%～96.2%) through the cyclization of the compounds Ⅱ with 1 mol/L K₂CO₃ solutionThe structures of compounds Ⅱ and Ⅲ were characterized by elemental analysis, IR, ¹H NMR and MS. Antibacterial activity tests of these compounds against BSubtills and EColi show that compounds Ⅱ_d-h, Ⅲ_d-h, are the most effective species.

Key words: Bis (1-Acetyl-4-aroylthiosemicarbazides), 1,2,4-Triazoline-5-thione, Antibacterial activity

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FENG Xiao-ming, CHEN Rong, YANG Wei-dong, ZHANG Zi-yi. Synthesis of Bis(1-Acetyl-4-Aroylthiosemicarbazides) and Their Derivatives[J]. Chem. J. Chinese Universities, 1992, 13(2): 187.

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Synthesis of Bis(1-Acetyl-4-Aroylthiosemicarbazides) and Their Derivatives

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