Preparation and Bio\|Evaluation of Iodine Labelling Gelatin Microspheres and the Coating Microspheres with Sodium Alginate

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (6): 1412.

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Preparation and Bio\|Evaluation of Iodine Labelling Gelatin Microspheres and the Coating Microspheres with Sodium Alginate

LUO Dong-Hui¹, LIU An-Ni¹, LI Ming-Fang¹, MA Yu², LI Lin², CHEN Xiao-Li², LIU Li¹, XIA Chuan-Qin^1*

1. College of Chemistry, Sichuan University, Chengdu 610064, China;
2. West China Hospital, Sichuan University, Chengdu 610041, China

Received:2010-07-09 Revised:2010-11-02 Online:2011-06-10 Published:2011-05-10
Contact: XIA Chuan-Qin E-mail:xiachqin@163.com
Supported by:
四川省科技支撑计划项目(批准号: 2009SZ0184)资助.

Abstract

Abstract: This paper describes a method to prepare the gelatin microspheres and the wrapped microspheres with sodium alginate（SA）. The microspheres were labeled with iodine-131,125 by Chloramine-T method and followed by injecting into the liver of rabbits. The characteristic comparisons of the gelatin microspheres and the wrapped microspheres were made and the results indicated that the wrapped microspheres can have a more iodine loading capacity and better stability than the gelatin microspheres. It also appeared that the degradation rate of wrapped microspheres is slower than the gelatin microspheres in physical condition. As a matter of fact the stability of iodine-131 in gelatin microspheres in the rabbits was evidenced by the ECT visualization: no visible radio-speck at the position of thyroid gland has been observed by injecting the wrapped microspheres, while the noticeable radio-speck of thyroid gland has been observed at the same site by injection of the gelatin microspheres, which proved that 131I in wrapped gelatin microsphere has better stability than in the gelatin microspheres.

Key words: Gelatin microspheres, iodine-131, iodine loading, Sodium alginate, stability

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LUO Dong-Hui, LIU An-Ni, LI Ming-Fang, MA Yu, LI Lin, CHEN Xiao-Li, LIU Li, XIA Chuan-Qin*. Preparation and Bio\|Evaluation of Iodine Labelling Gelatin Microspheres and the Coating Microspheres with Sodium Alginate[J]. Chem. J. Chinese Universities, 2011, 32(6): 1412.

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Preparation and Bio\|Evaluation of Iodine Labelling Gelatin Microspheres and the Coating Microspheres with Sodium Alginate

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