Surface Modification for Epoxy Resin Based Microfluidic Chip

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (6): 1272.

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Surface Modification for Epoxy Resin Based Microfluidic Chip

WANG Lin-Lin^1,2, HUANG Jiang¹, JIN Wei¹, JIN Qin-Han¹, MU Ying^1,2*

1. Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Labaratory of Industrial Control Technology, Zhejiang University, Hangzhou 310058, China;
2. Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun 130021, China

Received:2010-07-23 Revised:2010-10-19 Online:2011-06-10 Published:2011-05-10
Contact: MU Ying E-mail:ymu100@yahoo.com.cn
Supported by:
国家“九七三”计划项目(批准号: 2007CB714503, 2007CB714502), 国家科技部创新方法工作专项(批准号: 2008IM040800), 国家教育部博士学科点基金项目(批准号: 20090101110136 )和苏州市科技计划项目(批准号: ZXG0920)资助.

Abstract

Abstract: Microfluidic devices are potentially useful for biomedical detection， which sometimes need to be modified on the surface to immobilize active biomolecules. Surface modification of air-plasma-pretreated epoxy resin via near UV-induced graft polymerization with acrylic acid (AAc) was carried out. Specific antibodies were covalently immobilized on the surface of epoxy resin which were used to immunological detection. The modified epoxy resin were characterized by static water contact angle measurement, toluidine blue O staining test, X-ray photoelectron spectroscopy (XPS), bicinchoninic acid (BCA) test, and cell attachment. Our studies showed that the carboxyl groups were grafted onto the surface of epoxy resin, and covalently crosslinked with proteins. The results of cell attachment revealed that the modified epoxy resin could be applied to immunological detection.

Key words: Epoxy resin, Surface modification, Air plasma, UV-induced graft polymerization

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WANG Lin-Lin, HUANG Jiang, JIN Wei, JIN Qin-Han, MU Ying*. Surface Modification for Epoxy Resin Based Microfluidic Chip[J]. Chem. J. Chinese Universities, 2011, 32(6): 1272.

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Surface Modification for Epoxy Resin Based Microfluidic Chip

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