Electrospinning of PLGA/Gt Blend System

Chem. J. Chinese Universities

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Electrospinning of PLGA/Gt Blend System

ZHAO Jin^*, ZHAO Yu-Ping, ZHANG Wei, YUAN Xiao-Yan

School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University, Tianjin 300072, China

Received:2008-07-17 Revised:1900-01-01 Online:2009-02-10 Published:2009-02-10
Contact: ZHAO Jin

Abstract

Abstract: Poly(lactic-co-glycolic acid)/gelatin ultrafine composite fibers were fabricated via electrospinning. The effects of solution concentration, electric voltage and flow rate on the morphology of fibers were investigated. Also the morphology and mechanical properties of fiber membranes with different mass fraction of gelatin were studied. Results show ultrafine PLGA/gelatin fibers with narrow diameter distribution and little defect are obtained when solution concentration is 0.12 g/mL, voltage is 7.5 kV and flow rate is 0.8 mL/h. Compared with PLGA fibers, the diameter of PLGA/gelatin fibers reduced greatly. Addition of gelatin decreased the tensile strength and elongation of the membrane while increased the hydrophilicity. After immersing in PBS solution, the elasticity of PLGA/gelatin membranes increased. When mass fraction of gelatin was 5% and 10%, the diameter distribution was narrow. However, when it reached 15%, the distribution broadened.

Key words: Poly(lactic-co-glycolic acid), Gelatin, Electrospinning, Composite fibers, Morphology, Mechanical property

CLC Number:

O631

TrendMD:

ZHAO Jin^*, ZHAO Yu-Ping, ZHANG Wei, YUAN Xiao-Yan. Electrospinning of PLGA/Gt Blend System[J]. Chem. J. Chinese Universities, doi: .

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Electrospinning of PLGA/Gt Blend System

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