Syntheses and Crystal Structure of 1,5-Benzothiazepine Derivatives Containing Pyrazole

Chem. J. Chinese Universities

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Syntheses and Crystal Structure of 1,5-Benzothiazepine Derivatives Containing Pyrazole

XING Ye¹, XIE Zheng-Feng¹*, LIU Fang-Ming²*

1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education, Xinjiang University, Urumqi 830046, China;
2. College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, China

Received:2007-05-16 Revised:1900-01-01 Online:2008-03-10 Published:2008-03-10
Contact: LIU Fang-Ming, XIE Zheng-Feng

Abstract

Abstract: Ten chalcones were synthesized by Aldol condensation reaction of acetophenone or para-substituted acetophenones with 1-phenyl-3-methyl-5-aryloxyl- pyrazol-4-aldehyde under the strong alkali condition, then chalcones reacted with 2-aminobenzenethiol in glacial acetic acid under refluxing to give a series of 1,5-benzothiazepine which have potentially useful pharmacological properties. The compounds were confirmed by means of elemental analysis, IR spectrum, ¹H NMR and X-ray single-crystal diffraction analysis. The crystal of compound 6c belongs to a monoclinic system, space group P2(1)/n with cell parameters a=1.1793(2) nm, b=1.1907(2) nm, c=1.8726(4) nm, α=90°, β=104.71(3)°, γ=90°, M=522.04, V=2.5432(9) nm³, D_c=1.363 Mg/m³, Z=4, F(000)=1088.

Key words: Chalcone, 1,5-Benzothiazepine, Crystal structure

CLC Number:

O626

TrendMD:

XING Ye¹, XIE Zheng-Feng¹*, LIU Fang-Ming²*. Syntheses and Crystal Structure of 1,5-Benzothiazepine Derivatives Containing Pyrazole[J]. Chem. J. Chinese Universities, doi: .

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Syntheses and Crystal Structure of 1,5-Benzothiazepine Derivatives Containing Pyrazole

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