CJCU

Chem. J. Chinese Universities

• 研究论文 • Previous Articles     Next Articles

Orthogonal Test of Preparation of Poly(L-glutamic acid) Through Deprotection of Poly(γ-benzyl L-glutamate)

XIE Yong-Tao1, YIN Jing-Bo1*, ZHAO Chang-Wen2, CHEN Xue-Si2*   

    1. Department of Polymer Materials, Shanghai University, Shanghai 201800, China;
    2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2007-07-24 Revised:1900-01-01 Online:2008-01-10 Published:2008-01-10
  • Contact: YIN Jing-Bo

PDF (PC)

Abstract: Poly(L-glutamic acid)(PLGA) was prepared by removing the benzyl groups from poly(γ-benzyl L-glutamate)(PBLG) through 33%(volume fraction) HBr and acetic acid solution. Orthogonal test method was applied to study the effect of temperature, the reacting time, the quantity of the solvent and 33%HBr and acetic acid solution on the molecular weight of PLGA during the process of deprotection.The result show that PLGA molecular weight would be decreased with the increase of the temperature, the reacting time, and the solvent quantity, for the degradation of PBLG. However, the effect of HBr was reverse, for the acidity of 33%HBr and acetic acid solution was weaker than that of dichloroacedic acid(Cl2HAc), and PBLG could not be dissolved in 33%HBr and acetic acid solution.

Key words: Poly(γ-benzyl L-glutamate), Poly(L-glutamic acid), Deprotection, Orthogonal test

CLC Number: 

TrendMD: