Isolation of New Polyhydroxylated Sterol from Soft Coral Sarcophyton crassocaule Mosre

Chem. J. Chinese Universities

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Isolation of New Polyhydroxylated Sterol from Soft Coral Sarcophyton crassocaule Mosre

ZHANG Cui-Xian^1,2, YAN Su-Jun¹, ZHANG Guang-Wen³, SU Jing-Yu¹, ZENG Long-Mei¹*

1. School of Chemistry and Chemical Engineering , Sun Yat Sen University, Guangzhou 510275, China;
2. School of Taditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China;
3. Department of Food Science and Technology, Jinan University, Guangzhou 510632, China

Received:2006-05-06 Revised:1900-01-01 Online:2007-04-10 Published:2007-04-10
Contact: ZENG Long-Mei

Abstract

Abstract: In our continuing search of discovering bioactive substances from marine organisms, a sample of soft coral Sarcophyton crassocaule Mosre collected off the Sanya bay, China, was investigated. Two polyhydroxylated sterols 1 and 2 were isolated from the 95% ethanol extract of the sample by chromatography over silica gel. Compound 1, named sarcrasterol, was a new compound, its structure was established as(22R*,24ξ)-methyl-cholest-5-en-3β,22α,25,28-tetraol by spectroscopic methods. Compound 2, a known compound, was first obtained by Kobayashi, however, the relative configuration of C24 has not been determined yet. This paper reports the stereochemistry of compound 2 established as (24S*)-methyl cholest-3β,5β,6α,25-tetraol by means of X-ray single crystal diffraction analysis. Bioassay results show that compound 2 has a moderate activity against human tumor cell lines MGC-803 with an IC₅₀ value of 23.0 μg/mL.

Key words: Soft coral, Sarcophyton crassocaule, Polyhydroxylated sterols, Cytotoxicity

CLC Number:

O629.61

TrendMD:

ZHANG Cui-Xian^1,2, YAN Su-Jun¹, ZHANG Guang-Wen³, SU Jing-Yu¹, ZENG Long-Mei¹*. Isolation of New Polyhydroxylated Sterol from Soft Coral Sarcophyton crassocaule Mosre[J]. Chem. J. Chinese Universities, doi: .

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Isolation of New Polyhydroxylated Sterol from Soft Coral Sarcophyton crassocaule Mosre

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