Preparation of Molecularly Imprinted Polymer Microspheres and Their Recognition for Chenodeoxycholic Acid

Chem. J. Chinese Universities

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Preparation of Molecularly Imprinted Polymer Microspheres and Their Recognition for Chenodeoxycholic Acid

CHEN Fen-Qiang, LIU Shou-Xin*, FANG Yu, WANG Yi-Juan, ZHANG Zhao-Yang, JIANG Yu

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Materials Science, Shanxi Normal University, Xi'an 710062, China

Received:2007-05-16 Revised:1900-01-01 Online:2007-11-10 Published:2007-11-10
Contact: LIU Shou-Xin

Abstract

Abstract: Molecularly imprinted polymer microspheres were obtained by deposition polymerization with methyacrylic acid(MAA) as the functional monomer, trimethylolpropane trimethacrylate(TRIM) and ethylene glycoldimethacrylate(EDGMA) as the cross-linkers, chenodeoxycholic acid(CDCA) as the template molecule, and 2,2-azobis-isobutyronitrile as the initiation agent. The average size of the molecularly imprinted polymer microspheres was between 200 nm and 300 nm. The binding properties of the template molecule on MIPMS were evaluated by Scatchard analysis. The selective adsorptions of target molecule on MIPMS were studied. The results indicate that there were two class binding sites in polymers and the MIPMS showed a specific affinity toward chenodeoxycholic acid.

Key words: Deposition polymerization, Molecularly imprinted polymer microsphere, Molecular recognition, Chenodeoxycholic acid

CLC Number:

O631
O658

TrendMD:

CHEN Fen-Qiang, LIU Shou-Xin*, FANG Yu, WANG Yi-Juan, ZHANG Zhao-Yang, JIANG Yu. Preparation of Molecularly Imprinted Polymer Microspheres and Their Recognition for Chenodeoxycholic Acid[J]. Chem. J. Chinese Universities, doi: .

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Preparation of Molecularly Imprinted Polymer Microspheres and Their Recognition for Chenodeoxycholic Acid

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