Chem. J. Chinese Universities

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Side Reaction of Condensation Reagent 3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one(DEPBT) Caused by Imidazolyl Group

SHEN Hong-Yan; LIU Zhen-Ning; YAN Wan-Lin; YE Yun-Hua; TIAN Gui-Ling*   

  1. Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of
    Education, College of Chemistry and Molecular Engineering, Peking University,
    Beijing 100871, China
  • Received:2005-07-08 Revised:1900-01-01 Online:2006-07-10 Published:2006-07-10
  • Contact: TIAN Gui-Ling

Abstract: 3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one(DEPBT) condensation developed by our group is an effective organophosphorus condensation reagent for the synthesis of protected peptides containing Tyr, Ser and Thr with unprotected hydroxyl group on their side chain.

Key words: DEPBT, Histidine, Imidazolyl group, Side reaction

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