Chem. J. Chinese Universities ›› 2006, Vol. 27 ›› Issue (4): 669.

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Synthesis and Activity of Novel Sulfur-containing Peptidomimetic Inhibitors of Tumor Necrosis Factor

WANG Ding, ZHANG Qi-Han, XU Jia-Xi*   

  1. Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,
    College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • Received:2005-05-09 Online:2006-04-10 Published:2006-04-10
  • Contact: XU Jia-Xi,E-mail: jxxu@pku.edu.cn

Abstract:

Tumor necrosis factor is one of the important cell factors, which can regulate pro-imflammatory. On the basis of the known and efficient peptidomimetic inhibitors of tumor necrosis factor as the leading compounds, novel sulfur-containing peptidomimetic inhibitors were designed and synthesized in a convenient and efficient manner. Bioassay results indicate that three of them showed some inhibition activity on sTNF-α secretion in HL-60 cells induced by lipolysaccharide, and two of them showed a good stability and inhibition activity.

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