Synthesis and Antibacterial Activities of Some Indolizine Carboxylic Acids

doi:10.3969/j.issn.0251-0790.2012.08.016

Abstract

Abstract: A new procedure for the synthesis of indolizine carboxylic acids were developed. In the presence of tetrakispyridinecobalt(Ⅱ) dichromate (TPCD), indolizine carboxylic acid esters were readily synthesized by a one-pot reaction sequence which consists of a 1,3-dipolar cycloaddition of pyridinium N-ylides to alkenes, followed by an aromatization. Eigth indolizine carboxylic acids 3a-3c and 5a-5e were obtained in good yields by the direct hydrolysis of the crude indolizine carboxylic acid esters, and characterized by IR, ¹H NMR, MS and elemental analysis. The study on the antibacterial activity of these compounds against escherichia coli and staphylococcus aureus indicated that compounds 3a, 3c, 5a, 5c and 5d had a certain inhibitory effect on escherichia coli, while compounds 3a and 3c showed some inhibitory effect on staphylococcus aureus. Compound 3c showed good antimicrobial properties on these two strains.

Key words: Indolizine carboxylic acid, Inhibitory effect, Antibacterial activity

CLC Number:

O629

TrendMD:

JIANG Yu-Liang, XU Zhu-Xiong, WANG Bing-Xiang. Synthesis and Antibacterial Activities of Some Indolizine Carboxylic Acids[J]. Chem. J. Chinese Universities, 2012, 33(08): 1718.

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