Micro-structures and Mechanical Performance of Co-axial Nanofibers with Drug and Protein Cores and Polycaprolactone Shells

Abstract

Abstract: By a co-axial electrospinning technique, double-layered composite nanofibers with different core from shell materials can be fabricated. The composite nanofibers developed in this paper made use of some drug and a gelatin protein as cores and a biodegradable polymer, polycaprolactone, as shell. The micro-structures and mechanical performance of these nanofibers were characterized. It is shown that to encapsulate the drug in ultra-fine fibers whose wall thickness is less than 100 nm was achievable, even though the drug has a different dissolving solvent from that for the polymer shell material. Such kind of nanofibers can be used as sewing wires inside the human body or wound caring material for some heavy wounds such as burns. The tensile strengths of the nanofiber membranes decreased with the increase of the polymer concentrations in the core solutions.

Key words: Composite nanofibers, Electrospinning, Micro-structure, Mechanical property

CLC Number:

O631

TrendMD:

HUANG Zheng-Ming, ZHANG Yan-Zhong . Micro-structures and Mechanical Performance of Co-axial Nanofibers with Drug and Protein Cores and Polycaprolactone Shells[J]. Chem. J. Chinese Universities, 2005, 26(5): 968.

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Micro-structures and Mechanical Performance of Co-axial Nanofibers with Drug and Protein Cores and Polycaprolactone Shells

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