Voltammetric and Circular Dichroism Studies on Interaction Between 1, 4-Dihydropyridine Derivatives and DNA

Abstract

Abstract: The interactions of five kinds of 1,4-dihydropyridine(1,4-DHP) derivatives with calf thymus DNA(CT-DNA) were investigated by the electrochemical method and circular dichroism(CD). The results indicated that the interaction between 1,4-DHP derivatives and CT-DNA was in the intercalative mode. The strength of the interaction increases with the decrease in the steric hindrance of 1,4-DHP derivatives. DNA double helix in solution become more loose in the presence of non-planar structure 1,4-DHP derivatives.

Key words: Dihydropyridine derivatives, DNA, Electrochemistry, Circular dichroism, Oxidation peak, DNA conformation

CLC Number:

Q 523
O657

TrendMD:

DU Jiang-Yan, WANG Bing-Xiang, XU Fei, CHEN Ting-Ting, SHEN Zhu-Ying, SHEN Yong-Miao, XING Wei, LU Tian-Hong. Voltammetric and Circular Dichroism Studies on Interaction Between 1, 4-Dihydropyridine Derivatives and DNA[J]. Chem. J. Chinese Universities, 2005, 26(4): 663.

References

[1] Eisner U.,Kuthan J..Chem.Rev.[J],1972,72:1—42 [2] Loev B.,Goodman M.M.,Snader K.M.etal..Med.Chem.[J],1974,17:956—966 [3] Bossert F.,Vater W..Südafr.Pat.6 801 482[P],1968 [4] CHEN Hui-Min(陈慧民),YE Hui-Zen(叶慧珍).World Pharmacy(国外医药)[J],1994,15(2):72—73 [5] BAI Shu-Hua(白树华),CHEN Yu-Bin(陈玉彬).Advancesin Pharmacy(药学进展)[J],1999,23(1):13—14 [6] Lavilla R..J.Chem.Soc.,Perkin Trans.1[J],2002,(9):1141—1156 [7] Sabitha G.,Reddy G.A.K.K.,Reddy C.S.etal..Tetrahedron Lett.[J],2003,44(21):4129—4131 [8] Eynde J.J.V.,Mayence A..Molecules[J],2003,8:381—391 [9] DING Jun-Jie(丁俊杰),DING Xiao-Qin(丁晓琴),ZHAO Li-Feng(赵立峰)etal..Acta Phys.Chim.Sin.(物理化学学报)[J],2003,19(12):1108—1113 [10] CHENG Gui-Fang(程圭芳),ZHANG Dong-Mei(张冬梅),DING Min(丁敏)etal..Chem.J.Chinese Universities(高等学校化学学报)[J],2003,24(8):1395—1399 [11] Eynde J.J.V.,Delfosse F.,Mayence A.etal..Tetrahedron[J],1995,51:6511—6516 [12] Hinkel L.E.,Cremer H.W..J.Chem.Soc.[J],1920,117(8):137—142 [13] WANG Su-Fen(王素芬),PENG Tu-Zhi(彭图治),LI Jian-Ping(李建平).Chem.J.Chinese Universities(高等学校化学学报)[J],2003,24(8):1468—1471 [14] Carter M.T.,Bard A.J..J.Am.Chem.Soc.[J],1987,109:7528—7530 [15] Carter M.T.,Rodriguez M.,Bard A.J..J.Am.Chem.Soc.[J],1989,111:8901—8911 [16] Pang D.W.,Hector D.A..Anal.Chem.[J],1998,70:3162—3169 [17] ZHANG Li-Xin(张立新),WANG Bing-Xiang(王炳祥),ZHU Shi-Min(朱世民)etal..Chem.J.Chinese Universities(高等学校化学学报)[J],1997,18(11):1779—1782 [18] LIU Yong-Ming(刘永明),LI Gui-Zhi(李桂芝),JING Ji-Rong(荆济荣).Chin.J.Anal.Chem.(分析化学)[J],2002,30(11):1341—1343 [19] Zhang Z.L.,Huang W.M.,Tang J.L.etal..Biophy.Chem.[J],2002,97:7—16 [20] SONG Yu-Min((宋玉民),YANG Pei-Ju(杨培菊),WANG Liu-Fang(王流芳)etal..Acta Chimica Sinica(化学学报)[J],2003,61(8):1266—1270 [21] Yang P.,Wang H.F.,Gao F.etal..J.Inorg.Biochem.[J],1996,62:137—145 [22] ZHAO Bing-Jun(赵炳筠),ZHU Xiao-Qing(朱晓晴),HE Jia-Qi(何家骐)etal..Chem.J.Chinese Universities(高等学校化学学报)[J],1999,20(11):1733—1737 [23] TU Shu-Jiang(屠树江),MIAO Chun-Bao(缪春宝),GAO Yuan(高原)etal..Chin.J.Struct.Chem.(结构化学)[J],2002,21(2):222—226