Synthesis, Structure and Bioactivity of Nitrobenzoimidazole Derivatives

Abstract

Abstract:

It was reported that benzoimidazole and ferrocene compounds maybe exhibit high pharmaceutical functions. Eight new nitrobenzoimidazole derivatives were prepared by the reaction of ferrocene sulfonylchloride with 5-nitrobenzoimidazole and characterized by means of elemental analysis, MS and ¹H NMR. The structure of the new compounds was further confirmed by X-ray crystallograghic analysis as exemplified by compounds 3b. The activities of compounds 3a-4d were evaluated against five fungicides. Compared with carbendazim(50% wet powder), better inhibitory activities were observed for these synthesized compounds.

Key words: Nitrobenzoimidazole; Synthesis; Crystal structure; Antimicrobial activity, Nitrobenzoimidazole, Synthesis, Crystal structure, Antimicrobial activity

CLC Number:

O626.23

TrendMD:

WANG Lu-Yao, GAO Yong, YANG Bing-Qin, SHI Zhen. Synthesis, Structure and Bioactivity of Nitrobenzoimidazole Derivatives[J]. Chem. J. Chinese Universities, 2005, 26(12): 2241.

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Synthesis, Structure and Bioactivity of Nitrobenzoimidazole Derivatives

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