Synthesis of the Nd(Ⅲ) and Hbbimp Complex and Interaction Between the Complex and DNA

Abstract

Abstract: A new complex [Nd₂(bbimp)(CH₃COO)(CH₃CH₂O)₂(CH₃CH₂OH)](ClO₄)₂ was synthesized and characterized, in which Hbbimp is 2,6-bis[bis(2-benzimidazolylmethyl)]aminomethyl-4-methylphenoxo. The investigation on the interaction of both complex and CT DNA indicates that the absorbance value and the wave length at the maximum peak of CT DNA are reduced and red-shifted while the intensity of fluorescent spectra of EB-DNA is gradually weaken. UV melting curves prove the existence of the denaturation and degradation together. The only complex is capable of promoting the cleavage of pBR322 DNA at 50℃ and pH 8.0 and can translate most of the supercoiled DNA into nicked DNA. However, the supercoiled DNA can be absolutely translated into the nicked DNA when c(H₂O₂)<1×10^-3 mol/L and n(complex):n(H₂O₂) =1:20.

Key words: Binuclear Nd(Ⅲ) complex, Hbbimp, Synthesis, DNA

CLC Number:

O614

TrendMD:

ZHOU Chun-Qiong, DENG Xian-He, LIU Gang, YANG Pin . Synthesis of the Nd(Ⅲ) and Hbbimp Complex and Interaction Between the Complex and DNA[J]. Chem. J. Chinese Universities, 2004, 25(9): 1608.

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Synthesis of the Nd(Ⅲ) and Hbbimp Complex and Interaction Between the Complex and DNA

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