Synthesis and Anti-liver Cancer Activity of 5-Fluorouracil Salt of 12-Tungstoboric Acid

Abstract

Abstract: 5-Fluorouracil salt(WBF) of 12-tungstoboric acid with Keggin structure was synthesized and its structure was characterized by IR, ¹H NMR, ¹⁸³ W NMR and elementary analysis. The MTT experimental results show that WBF has a stronger killing ability for liver cancer cells in vitro. The acute toxicity of WBF was carried out. The half toxicity dose LD₅₀ of WBF orally administrated to mice is 1 117.4 mg/kg.

Key words: Tungstoboric acid, 5-Fluorouracil, Synthesis, Anti-liver cancer activity

CLC Number:

O614

TrendMD:

LI Juan, LI Jing, QI Yan-Fei, WANG Hong-Fang, WANG En-Bo, HU Chang-Wen, XU Lin, WU Xin-Yu. Synthesis and Anti-liver Cancer Activity of 5-Fluorouracil Salt of 12-Tungstoboric Acid[J]. Chem. J. Chinese Universities, 2004, 25(6): 1010.

References

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