Synthesis of Novel Type ALS Inhibitors Based on Pharmacophore Model Design

Abstract

Abstract: Derived from the postulated ALS inhibitors′ pharmacophore model, the generalized function-based queries were defined and used for three-dimensional(3D) searching in two different 3D databases(NCI-3D and ACD-3D). More than 100 novel structural hits were found by performing different 3D searching programs(3DFS and ISIS/3D). The novel structure hits provide a lot of structural information, the novel type ALS inhibitors were designed and synthesized by the information. The preliminary bioassay data indicate that some compounds with an anticipated good biological activity have ALS inhibitions in some degree.

Key words: ALS inhibitors, Pharmacophore model, Design, Synthesis, Bioactivity

CLC Number:

O626

TrendMD:

CHENG Yong-Hao, CHEN Kai, LI Yong-Hong, ZOU Xiao-Mao, YANG Hua-Zheng . Synthesis of Novel Type ALS Inhibitors Based on Pharmacophore Model Design[J]. Chem. J. Chinese Universities, 2004, 25(2): 276.

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Synthesis of Novel Type ALS Inhibitors Based on Pharmacophore Model Design

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