Synthesis and Biological Activity of Novel 1-(Substituted-pyrazole-4-carbonyl) Pyrazoles

Abstract

Abstract: A series of new 1-(substituted-pyrazole-4-carbonyl)-pyrazoles were synthesized by the reaction of 5-amino-1-methyl-3-(methylthio)-¹H-pyrazole-4-carbohydrazide and 5-amino-1-methyl-¹H-pyrazole-4-carbohydrazide respectively with 2-cyano-3,3-bis(alkylthio) acrylates or 2-[bis(alkylthio)methylene] malononitriles. All the compounds were structurally confirmed by elemental analysis and ¹H NMR. Their herbicidal activities were tested. Bioassay results showed that some of them had herbicidal activities. The structure-activity relationship was discussed, which indicated the substituents on the pyrazole ring have influence on the title compounds activities.

Key words: HPPD inhibitor, Synthesis, Pyrazole, Biological activity, Structure-activity relationship

CLC Number:

O626

TrendMD:

CHENG Yong-Hao, ZOU Xiao-Mao, GAO Ying, YANG Hua-Zheng. Synthesis and Biological Activity of Novel 1-(Substituted-pyrazole-4-carbonyl) Pyrazoles[J]. Chem. J. Chinese Universities, 2004, 25(11): 2024.

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Synthesis and Biological Activity of Novel 1-(Substituted-pyrazole-4-carbonyl) Pyrazoles

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