Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (9): 1709.

• Articles • Previous Articles     Next Articles

Synthesis and Bioactivity of 5-Avermectin B1a Esters

LIAO Lian-An1, LI Zheng-Ming2, FANG Hong-Yun1, ZHAO Wei-Guang2, CHEN Ming-De1, FAN Zhi-Jin2, LIU Gui-Long2   

  1. 1. Depa rtment of Chemistry, Xiamen University, Xiamen 361005, China;
    2. Instituteof Emento-organic Chemistry, State Key Laboratoryof Elemento-Organic Chemistry, Nanka i University, Tianjin 300071, China
  • Received:2001-06-18 Online:2002-09-24 Published:2002-09-24

Abstract: Ten 5-Avermectin B1a ester derivatives were prepared from avermectin B1a and carboxylic acids in the systems of DCC/DMAP. Their chemical structures were confirmed by IR, 1H NMR, 13C NMR and MS. Their insecticidal activity was evaluated against Aphis gossypii Glover and Tetranychus truncatus Ehara. It was found that some compounds showed a higher insecticidal activity than Avermectin.

Key words: Avermectin B1a, Bioactivity, Esterification, DMAP/DCC

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