Synthesis of Novel Metalloporphyrins and Their Biological Activityas Mimics of Enzymes

Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (5): 756.

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Synthesis of Novel Metalloporphyrins and Their Biological Activityas Mimics of Enzymes

LI Zao-Ying¹, ZHANG Yue-Ning¹, ZHU Xun-Jin¹, FENG Qing²

1. College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China;
2. College of Tongji Medicine, Huazhong University of Science and Technology, Wuhan 430030, China

Received:2001-07-27 Online:2002-05-24 Published:2002-05-24

Abstract

Abstract: Based on 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin(2),a series of non-water soluble and water-soluble metalloporphyrins were synthesized.As mimics of SOD (superoxide dismutase) and CAT(catalase) enzymes, metalloporphyrins 3a-3e, 5a-5f,and 8a-8f, were tested in the assays to dismutase O₂^-, to decompose H₂O₂,to clear OH,and to eliminate lipid peroxidation produced in the ho-mogenated livers of mice.Among these metalloporphyrins, 8a-8f, were most effective.Some rules were obtained from the biological activity testing results.

Key words: Metalloporphyrins, Synthesis, Characterizaion, Determination of Biological activity of mimic enzymes

CLC Number:

O623.13

TrendMD:

LI Zao-Ying, ZHANG Yue-Ning, ZHU Xun-Jin, FENG Qing. Synthesis of Novel Metalloporphyrins and Their Biological Activityas Mimics of Enzymes[J]. Chem. J. Chinese Universities, 2002, 23(5): 756.

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Synthesis of Novel Metalloporphyrins and Their Biological Activityas Mimics of Enzymes

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