Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (4): 610.

• Articles • Previous Articles     Next Articles

A Review of Delta-Sleep-Inducing Peptide

ZHOU Chuang, TIAN Gui-Ling, YE Yun-Hua   

  1. Key Laboratory of Bioorganic and Molecular Engineering of Education Ministry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • Received:2000-12-22 Online:2002-04-24 Published:2002-04-24

Abstract: Delta sleep-inducing peptide (DSIP) was the first sleep-factor whose chemical structure hasbeen identified.Synthesis of DSIPby means of various methods, such as solution method, solid phasemethod, enzymatic promotion method and genetic engineering method, was discussed.Some new biologi-cal activities other than the somnogenic effect of DSIPwere introduced.The structure-activity relationship(SAR) of DSIPand con formational study of this peptide in solution were also presented.Some approachesof further studies on DSIPwere suggested.

Key words: Delta sleep-inducing peptide, Synthesis, Biological activities, Structure-activity relationship

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