Arabinogalactan as a Carrier for Contrast Agent in Magnetic Resonance Imaging

Abstract

Abstract: Arabinogalactan-Gd-DTPA was synthesized by the reaction of diethylenetriaminepenta-acetic acid(DTPA) bisanhydride with polysaccharide in dry DMSO and characterized by FTIR, elemental analysis and ICP-AES. Its stability was investigated by competition with Ca²⁺, EDTA, DTPA. The t₁-relaxivity is 8.06 mmol^-1·L·s^-1 in D 2O, 8.48 mmol^-1·L·s^-1 in 0.725 mmol·L^-1 BSA, respectively. t₁-weighted MR imaging of rat kidney and liver showed a remarkable enhancement post injection of Arabinogalactan-Gd-DTPA. The results indicate that the arabinogalactan-Gd-DTPA is a potential contrast agent for MRI.

Key words: Arabinogalactan, Magnetic resonance imaging, Contrast agent, Relaxivity

CLC Number:

O657.2

TrendMD:

SUN Guo-Ying, FENG Jiang-Hua, JING Feng-Ying, PEI Feng-Kui . Arabinogalactan as a Carrier for Contrast Agent in Magnetic Resonance Imaging[J]. Chem. J. Chinese Universities, 2002, 23(10): 1837.

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Arabinogalactan as a Carrier for Contrast Agent in Magnetic Resonance Imaging

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