Preparation and Biodistribution of a Novel Potential Blood Pool Imaging Agent Technetium-99m Labeled COI Complexes

Abstract

Abstract: The objective of this study is to develop a new potential cardiac blood pool imaging agent. An isonitrile ligand cyclooctylisonitrile(COI) is synthesized and a copper salt[Cu(Ⅰ)(COI) ₄BF₄] of this ligand is also prepared, the isonitrile and it′s copper salt are characterized by IR and elemental analysis. The complex ^99mTcN-COI is prepared by ligand exchange reaction while the complex ^99mTc-COI is prepared by a direct labeling method. The results of stability study indicated that both complexes are stable over a period of 6 h at room temperature. The biodistribution of these new complexes in mice indicated that they had significantly different uptake properties in most tissues. But they are all mainly accumulated in blood and maintained in it very good. Especially the T/NT ratios of ^99mTc-COI in mice are excellent as a cardiac blood pool imaging agent. Based on its promising properties, the complex ^99mTc-COI maybe suitable for cardiac blood pool imaging.

Key words: Technetium-99m, Cardiac blood pool imaging agent, COI, ^99mTcN-COI, ^99mTc-COI, Biodistribution in mice

CLC Number:

O615.4

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ZHANG Xian-Zhong, ZHOU Jin-Ming, WANG Xue-Bin. Preparation and Biodistribution of a Novel Potential Blood Pool Imaging Agent Technetium-99m Labeled COI Complexes[J]. Chem. J. Chinese Universities, 2002, 23(10): 1829.

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Preparation and Biodistribution of a Novel Potential Blood Pool Imaging Agent Technetium-99m Labeled COI Complexes

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