Chem. J. Chinese Universities ›› 2001, Vol. 22 ›› Issue (7): 1122.

• Articles • Previous Articles     Next Articles

Investigation of Separation of Caffeine and Theophylline on Molecular Imprinted Polymer Stationary Phases by High Performance Liquid Chromatography

SU Li-Qiang1, LIU Xue-Liang2, WANG Jun-De2, SHANG Zhen-Hua2   

  1. 1. School of Chemical Engineering, Qiqiha'er University, Qiqihar 161006, China;
    2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116012, China
  • Received:2000-08-10 Online:2001-07-24 Published:2001-07-24

Abstract: Molecularly imprinted polymer(MIP) stationary phases against caffeine and against theophylline were prepared. Separation abilities of the phases were investigated by HPLC. The results showed that the theophylline based MIPstationary phase is highly selective to theophylline, and base-lined separation of caffeine and theophylline was achieved. However, the caffeine based MIPstationary phase did not possess specific selectivity to the template molecule, caffeine. MIPwith specific selectivity to template molecule can only be prepared when interactions between template and monomer go together.

Key words: High performance liquid chromatography, Molecular imprinted polymer, Caffeine, Theophylline

CLC Number: 

TrendMD: