Electrochemical Studies of Mitoxantrone Interaction with DNA at a Ni/GC Ion Implantation Modified Electrode

Abstract

Abstract: The electrochemical behavior of mitoxantrone interaction with DNAat a Ni/GCmodified electrode was studied by linear sweep and cyclic voltammetry. In_0.05 mol/L Tris-0.5mol/L NaCl solution (pH=7.1), the reaction of DNAwith MXformed an electrochemically nonactive complex, resulting in a decrease in the MXequilibrium concentration and its reduction current. The composition of the complex was n (MX): n (DNA)=2:1. The combining constant was 1.61×10¹². The electrode reaction rate constant k⁰ and the electron transfer coefficient α were 0.33 s^-1 and 0.41, respectively. The decrease in peak current was proportional to DNAconcentration and can be used to determine DNAconcentration.

Key words: Mitoxantrone, DNA, Ion implantation, Modified electrode, Electrochemical behavior

CLC Number:

O657

TrendMD:

HU Jin-Bo, SHANG Jun, LI Qi-Long . Electrochemical Studies of Mitoxantrone Interaction with DNA at a Ni/GC Ion Implantation Modified Electrode[J]. Chem. J. Chinese Universities, 2001, 22(5): 749.

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Electrochemical Studies of Mitoxantrone Interaction with DNA at a Ni/GC Ion Implantation Modified Electrode

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